Antimicrobial Coatings Based on Hybrid Iron Oxide Nanoparticles

Antimicrobial Coatings Based on Hybrid Iron Oxide Nanoparticles

This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. Fe<sub>3</sub>O<sub>4</sub> nanoparticles were synthesized and simultaneously functionalized w...

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Main Authors: Doina-Antonia Mercan, Dana-Ionela Tudorache (Trifa), Adelina-Gabriela Niculescu, Laurenţiu Mogoantă, George Dan Mogoşanu, Alexandra Cătălina Bîrcă, Bogdan Ștefan Vasile, Ariana Hudiță, Ionela Cristina Voinea, Miruna S. Stan, Tony Hadibarata, Dan Eduard Mihaiescu, Alexandru Mihai Grumezescu, Adina Alberts
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Nanomaterials
Subjects:
iron oxide nanoparticles
microfluidic synthesis
double functionalization
antimicrobial activity
silver
copper oxide
Online Access:https://www.mdpi.com/2079-4991/15/9/637
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Summary:This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. Fe<sub>3</sub>O<sub>4</sub> nanoparticles were synthesized and simultaneously functionalized with salicylic acid using a three-dimensional vortex-type microfluidic chip, enabling rapid and uniform particle formation. The resulting Fe<sub>3</sub>O<sub>4</sub>/SA nanostructures were further modified with either silver or copper oxide to form iron oxide nanocomposites with enhanced antimicrobial functionality. These nanocomposites were subsequently integrated into silica aerogel matrices using a dip-coating approach to improve surface dispersion, structural stability, and biocompatibility. The structural and morphological properties of the samples were investigated using XRD, FT-IR, TEM with SAED analysis, and Raman microscopy. In vitro cytotoxicity and antimicrobial assays demonstrated that Fe<sub>3</sub>O<sub>4</sub>/SA–Ag and Fe<sub>3</sub>O<sub>4</sub>/SA–CuO exhibit potent antibacterial activity and cell type-dependent biocompatibility. In vivo biodistribution studies showed no accumulation in major organs and selective clearance via the spleen, validating the systemic safety of the platform. These findings highlight the potential of the synthesized nanocomposites as biocompatible, antimicrobial coatings for advanced biomedical surfaces.
ISSN:2079-4991

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