Vitamin D Deficiency in Cystic Fibrosis
Cystic Fibrosis is the most common inherited genetic respiratory disorder in the Western World. Hypovitaminosis D is almost universal in CF patients, likely due to a combination of inadequate absorption, impaired metabolism, and lack of sun exposure. Inadequate levels are associated with the high pr...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/218691 |
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| _version_ | 1849744312114348032 |
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| author | William B. Hall Amy A. Sparks Robert M. Aris |
| author_facet | William B. Hall Amy A. Sparks Robert M. Aris |
| author_sort | William B. Hall |
| collection | DOAJ |
| description | Cystic Fibrosis is the most common inherited genetic respiratory disorder in the Western World. Hypovitaminosis D is almost universal in CF patients, likely due to a combination of inadequate absorption, impaired metabolism, and lack of sun exposure. Inadequate levels are associated with the high prevalence of bone disease or osteoporosis in CF patients, which is associated with increased morbidity including fractures, kyphosis, and worsening pulmonary status. Treatment goals include regular monitoring 25 hydroxyvitamin D (25OHD) levels with aggressive treatment for those with levels <75 nmol/L (<30 ng/mL). More research is needed to determine optimal supplementation goals and strategies. |
| format | Article |
| id | doaj-art-e0591277204442ce9c2a9d8555cb93b7 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e0591277204442ce9c2a9d8555cb93b72025-08-20T03:20:58ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/218691218691Vitamin D Deficiency in Cystic FibrosisWilliam B. Hall0Amy A. Sparks1Robert M. Aris2Division of Pulmonary and Critical Care Medicine and the School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADivision of Pulmonary and Critical Care Medicine and the School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADivision of Pulmonary and Critical Care Medicine and the School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USACystic Fibrosis is the most common inherited genetic respiratory disorder in the Western World. Hypovitaminosis D is almost universal in CF patients, likely due to a combination of inadequate absorption, impaired metabolism, and lack of sun exposure. Inadequate levels are associated with the high prevalence of bone disease or osteoporosis in CF patients, which is associated with increased morbidity including fractures, kyphosis, and worsening pulmonary status. Treatment goals include regular monitoring 25 hydroxyvitamin D (25OHD) levels with aggressive treatment for those with levels <75 nmol/L (<30 ng/mL). More research is needed to determine optimal supplementation goals and strategies.http://dx.doi.org/10.1155/2010/218691 |
| spellingShingle | William B. Hall Amy A. Sparks Robert M. Aris Vitamin D Deficiency in Cystic Fibrosis International Journal of Endocrinology |
| title | Vitamin D Deficiency in Cystic Fibrosis |
| title_full | Vitamin D Deficiency in Cystic Fibrosis |
| title_fullStr | Vitamin D Deficiency in Cystic Fibrosis |
| title_full_unstemmed | Vitamin D Deficiency in Cystic Fibrosis |
| title_short | Vitamin D Deficiency in Cystic Fibrosis |
| title_sort | vitamin d deficiency in cystic fibrosis |
| url | http://dx.doi.org/10.1155/2010/218691 |
| work_keys_str_mv | AT williambhall vitaminddeficiencyincysticfibrosis AT amyasparks vitaminddeficiencyincysticfibrosis AT robertmaris vitaminddeficiencyincysticfibrosis |