Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress

Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress

Background and PurposeCisplatin is a widely used chemotherapy drug for the treatment of solid tumours, but its clinical benefit is often limited by ototoxicity, leading to irreversible sensorineural hearing loss. However, there is a lack of effective strategies to prevent hearing loss caused by cisp...

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Bibliographic Details
Main Authors: Zhifeng Chen, Ting Xie, Chenyu Chen, Tingting Lin, Xiaobo Wu, Yuqing Chen, Yanchun Lin, Xiaoyang Luo, Chaojun Zeng, Chang Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
sarsasapogenin
ototoxicity
cisplatin
apoptosis
ferroptosis
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1641174/full
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