Cold Agglutinin Disease–Associated Transient Ischemic Attack, Non-ST Elevation Myocardial Infarction, and Skin Necrosis: A Case Report
Cold agglutinin disease is a rare autoimmune hemolytic anemia that preferentially affects female patients and is more common in those older than 60 years. The pathophysiology involves IgM autoantibodies against erythrocytes in areas of the body at cooler temperatures, causing thrombosis and hemolysi...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2023-08-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0909 |
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| author | David Aziz Rachel Parks Ashley Barras George Mina Christopher Haas Suraj Jande |
| author_facet | David Aziz Rachel Parks Ashley Barras George Mina Christopher Haas Suraj Jande |
| author_sort | David Aziz |
| collection | DOAJ |
| description | Cold agglutinin disease is a rare autoimmune hemolytic anemia that preferentially affects female patients and is more common in those older than 60 years. The pathophysiology involves IgM autoantibodies against erythrocytes in areas of the body at cooler temperatures, causing thrombosis and hemolysis. We present the case of a 66-year-old man who was found to have cold agglutinin disease and initially presented with altered mental status, stroke-like symptoms, and non-ST elevation myocardial infarction. Overnight, he also developed striking soft-tissue necrosis of his bilateral feet due to microvascular occlusion. His altered mentation and cardiac ischemia completely resolved; however, he eventually required bilateral phalangeal amputation. |
| format | Article |
| id | doaj-art-e053d16d10584019a507c24bf0b37f9a |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-e053d16d10584019a507c24bf0b37f9a2025-08-20T03:18:11ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642023-08-012810.7326/aimcc.2022.0909Cold Agglutinin Disease–Associated Transient Ischemic Attack, Non-ST Elevation Myocardial Infarction, and Skin Necrosis: A Case ReportDavid Aziz0Rachel Parks1Ashley Barras2George Mina3Christopher Haas4Suraj Jande51Louisiana State University Health Sciences Center at Shreveport. Department of Internal Medicine, Shreveport, Louisiana1Louisiana State University Health Sciences Center at Shreveport. Department of Internal Medicine, Shreveport, Louisiana1Louisiana State University Health Sciences Center at Shreveport. Department of Internal Medicine, Shreveport, Louisiana1Louisiana State University Health Sciences Center at Shreveport. Department of Internal Medicine, Shreveport, Louisiana1Louisiana State University Health Sciences Center at Shreveport. Department of Internal Medicine, Shreveport, Louisiana1Louisiana State University Health Sciences Center at Shreveport. Department of Internal Medicine, Shreveport, LouisianaCold agglutinin disease is a rare autoimmune hemolytic anemia that preferentially affects female patients and is more common in those older than 60 years. The pathophysiology involves IgM autoantibodies against erythrocytes in areas of the body at cooler temperatures, causing thrombosis and hemolysis. We present the case of a 66-year-old man who was found to have cold agglutinin disease and initially presented with altered mental status, stroke-like symptoms, and non-ST elevation myocardial infarction. Overnight, he also developed striking soft-tissue necrosis of his bilateral feet due to microvascular occlusion. His altered mentation and cardiac ischemia completely resolved; however, he eventually required bilateral phalangeal amputation.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0909 |
| spellingShingle | David Aziz Rachel Parks Ashley Barras George Mina Christopher Haas Suraj Jande Cold Agglutinin Disease–Associated Transient Ischemic Attack, Non-ST Elevation Myocardial Infarction, and Skin Necrosis: A Case Report Annals of Internal Medicine: Clinical Cases |
| title | Cold Agglutinin Disease–Associated Transient Ischemic Attack, Non-ST Elevation Myocardial Infarction, and Skin Necrosis: A Case Report |
| title_full | Cold Agglutinin Disease–Associated Transient Ischemic Attack, Non-ST Elevation Myocardial Infarction, and Skin Necrosis: A Case Report |
| title_fullStr | Cold Agglutinin Disease–Associated Transient Ischemic Attack, Non-ST Elevation Myocardial Infarction, and Skin Necrosis: A Case Report |
| title_full_unstemmed | Cold Agglutinin Disease–Associated Transient Ischemic Attack, Non-ST Elevation Myocardial Infarction, and Skin Necrosis: A Case Report |
| title_short | Cold Agglutinin Disease–Associated Transient Ischemic Attack, Non-ST Elevation Myocardial Infarction, and Skin Necrosis: A Case Report |
| title_sort | cold agglutinin disease associated transient ischemic attack non st elevation myocardial infarction and skin necrosis a case report |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0909 |
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