Tumour-Derived, Extracellular Microvesicles in the Treatment of Acute Renal Failure: An Experimental Study
<b>Background/Objectives</b>: This investigation compared the therapeutic efficacy of extracellular microvesicles (MVs) derived from murine L929 sarcoma cells and murine mesenchymal stem cells (MSCs). <b>Methods</b>: A mouse model of acute kidney injury (AKI) was used. <b&...
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| Format: | Article |
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MDPI AG
2025-04-01
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| Series: | Medical Sciences |
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| Online Access: | https://www.mdpi.com/2076-3271/13/2/35 |
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| author | Galina V. Seledtsova Victor I. Seledtsov Ayana B. Dorzhieva Irina P. Ivanova Tatiana S. Khabalova Adas Darinskas Alexei A. von Delwig |
| author_facet | Galina V. Seledtsova Victor I. Seledtsov Ayana B. Dorzhieva Irina P. Ivanova Tatiana S. Khabalova Adas Darinskas Alexei A. von Delwig |
| author_sort | Galina V. Seledtsova |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: This investigation compared the therapeutic efficacy of extracellular microvesicles (MVs) derived from murine L929 sarcoma cells and murine mesenchymal stem cells (MSCs). <b>Methods</b>: A mouse model of acute kidney injury (AKI) was used. <b>Results</b>: Both MVs from L929 cells (L929-MVs) and MSCs (MSC-MVs), unlike those obtained from murine peripheral blood mononuclear cells (PBMCs), enhanced survival rates in AKI mice and significantly improved kidney function. This was indicated by decreased levels of urine albumin and serum creatinine. Furthermore, treatment with L929-MVs and MSC-MVs elevated the proportions of CD4+CD25+FOXP3+ regulatory T cells while reducing the presence of pro-inflammatory CD4+CD44+ T cells in the spleens of AKI mice. <b>Conclusions</b>: the results highlight the potential of tumour-derived MVs to facilitate organ repair and exert cytoprotective immunomodulatory effects. |
| format | Article |
| id | doaj-art-e053a2145eb34393ae842623ff93c4d8 |
| institution | Kabale University |
| issn | 2076-3271 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj-art-e053a2145eb34393ae842623ff93c4d82025-08-20T03:27:28ZengMDPI AGMedical Sciences2076-32712025-04-011323510.3390/medsci13020035Tumour-Derived, Extracellular Microvesicles in the Treatment of Acute Renal Failure: An Experimental StudyGalina V. Seledtsova0Victor I. Seledtsov1Ayana B. Dorzhieva2Irina P. Ivanova3Tatiana S. Khabalova4Adas Darinskas5Alexei A. von Delwig6Institute for Fundamental and Clinical Immunology, 630099 Novosibirsk, RussiaPetrovsky National Research Centre of Surgery, 119991 Moscow, RussiaInstitute for Fundamental and Clinical Immunology, 630099 Novosibirsk, RussiaInstitute for Fundamental and Clinical Immunology, 630099 Novosibirsk, RussiaInstitute for Fundamental and Clinical Immunology, 630099 Novosibirsk, RussiaNational Cancer Institute, 08406 Vilnius, LithuaniaInstitute for Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia<b>Background/Objectives</b>: This investigation compared the therapeutic efficacy of extracellular microvesicles (MVs) derived from murine L929 sarcoma cells and murine mesenchymal stem cells (MSCs). <b>Methods</b>: A mouse model of acute kidney injury (AKI) was used. <b>Results</b>: Both MVs from L929 cells (L929-MVs) and MSCs (MSC-MVs), unlike those obtained from murine peripheral blood mononuclear cells (PBMCs), enhanced survival rates in AKI mice and significantly improved kidney function. This was indicated by decreased levels of urine albumin and serum creatinine. Furthermore, treatment with L929-MVs and MSC-MVs elevated the proportions of CD4+CD25+FOXP3+ regulatory T cells while reducing the presence of pro-inflammatory CD4+CD44+ T cells in the spleens of AKI mice. <b>Conclusions</b>: the results highlight the potential of tumour-derived MVs to facilitate organ repair and exert cytoprotective immunomodulatory effects.https://www.mdpi.com/2076-3271/13/2/35acute kidney injurytumourmesenchymal stem cellmicrovesiclesregeneration |
| spellingShingle | Galina V. Seledtsova Victor I. Seledtsov Ayana B. Dorzhieva Irina P. Ivanova Tatiana S. Khabalova Adas Darinskas Alexei A. von Delwig Tumour-Derived, Extracellular Microvesicles in the Treatment of Acute Renal Failure: An Experimental Study Medical Sciences acute kidney injury tumour mesenchymal stem cell microvesicles regeneration |
| title | Tumour-Derived, Extracellular Microvesicles in the Treatment of Acute Renal Failure: An Experimental Study |
| title_full | Tumour-Derived, Extracellular Microvesicles in the Treatment of Acute Renal Failure: An Experimental Study |
| title_fullStr | Tumour-Derived, Extracellular Microvesicles in the Treatment of Acute Renal Failure: An Experimental Study |
| title_full_unstemmed | Tumour-Derived, Extracellular Microvesicles in the Treatment of Acute Renal Failure: An Experimental Study |
| title_short | Tumour-Derived, Extracellular Microvesicles in the Treatment of Acute Renal Failure: An Experimental Study |
| title_sort | tumour derived extracellular microvesicles in the treatment of acute renal failure an experimental study |
| topic | acute kidney injury tumour mesenchymal stem cell microvesicles regeneration |
| url | https://www.mdpi.com/2076-3271/13/2/35 |
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