The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation
Abstract Ankyrin repeat (AR) motif is one of the most abundant repeat motifs found in eukaryotic proteins. It functions in mediating protein–protein interactions and regulating numerous biological functions. Interestingly, some AR-containing proteins are involved in epigenetic and transcriptional ev...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-05-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02519-4 |
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| _version_ | 1849728263132282880 |
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| author | Meijuan Wu Yulu Zhao Jiahe Yang Fangyuan Yang Yeyang Dai Qian Wang Cheng Chen Xiaoyuan Chu |
| author_facet | Meijuan Wu Yulu Zhao Jiahe Yang Fangyuan Yang Yeyang Dai Qian Wang Cheng Chen Xiaoyuan Chu |
| author_sort | Meijuan Wu |
| collection | DOAJ |
| description | Abstract Ankyrin repeat (AR) motif is one of the most abundant repeat motifs found in eukaryotic proteins. It functions in mediating protein–protein interactions and regulating numerous biological functions. Interestingly, some AR-containing proteins are involved in epigenetic and transcriptional events. Our review aims to characterize the structure and post-translational modification of AR, summarize the prominent role of AR-containing proteins in epigenetic and transcriptional events, emphasizing the crucial functions mediated by AR motifs. |
| format | Article |
| id | doaj-art-e0537ea5b9f1424394349072e640c2e8 |
| institution | DOAJ |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-e0537ea5b9f1424394349072e640c2e82025-08-20T03:09:35ZengNature Publishing GroupCell Death Discovery2058-77162025-05-011111910.1038/s41420-025-02519-4The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulationMeijuan Wu0Yulu Zhao1Jiahe Yang2Fangyuan Yang3Yeyang Dai4Qian Wang5Cheng Chen6Xiaoyuan Chu7Department of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Medical Oncology, Jinling Hospital, Nanjing Medical UniversityDepartment of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical UniversityDepartment of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityAbstract Ankyrin repeat (AR) motif is one of the most abundant repeat motifs found in eukaryotic proteins. It functions in mediating protein–protein interactions and regulating numerous biological functions. Interestingly, some AR-containing proteins are involved in epigenetic and transcriptional events. Our review aims to characterize the structure and post-translational modification of AR, summarize the prominent role of AR-containing proteins in epigenetic and transcriptional events, emphasizing the crucial functions mediated by AR motifs.https://doi.org/10.1038/s41420-025-02519-4 |
| spellingShingle | Meijuan Wu Yulu Zhao Jiahe Yang Fangyuan Yang Yeyang Dai Qian Wang Cheng Chen Xiaoyuan Chu The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation Cell Death Discovery |
| title | The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation |
| title_full | The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation |
| title_fullStr | The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation |
| title_full_unstemmed | The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation |
| title_short | The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation |
| title_sort | role of ankyrin repeat containing proteins in epigenetic and transcriptional regulation |
| url | https://doi.org/10.1038/s41420-025-02519-4 |
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