Therapeutic efficacy of mesenchymal stem cells for cardiovascular diseases
Despite the improvements in pharmacological and surgical treatments, cardiovascular diseases (CVDs) are the number one cause of death worldwide. During the last two decades, the search for new therapies has been revolutionized with the growing knowledge of stem cell biology. Due to their huge differ...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Journal of Mind and Medical Sciences |
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| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1280&context=jmms |
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| _version_ | 1850273711939125248 |
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| author | Dragana Radoje Miloradovic Dragica Radoje Pavlovic Miodrag Bozidar Stojkovic Sanja Bratislav Bojic Vladislav Bogdan Volarevic Marina Milosav Gazdic Jankovic Biljana Tomislav Ljujic |
| author_facet | Dragana Radoje Miloradovic Dragica Radoje Pavlovic Miodrag Bozidar Stojkovic Sanja Bratislav Bojic Vladislav Bogdan Volarevic Marina Milosav Gazdic Jankovic Biljana Tomislav Ljujic |
| author_sort | Dragana Radoje Miloradovic |
| collection | DOAJ |
| description | Despite the improvements in pharmacological and surgical treatments, cardiovascular diseases (CVDs) are the number one cause of death worldwide. During the last two decades, the search for new therapies has been revolutionized with the growing knowledge of stem cell biology. Due to their huge differentiation capacity and paracrine effects, mesenchymal stem cells (MSCs) are a promising tool for the treatment of CVDs. The encouraging outcomes of preclinical studies using MSCs as a treatment for diseased myocardium have set the scene for worldwide clinical trials. In this review, we overview either complete or ongoing clinical trials using MSCs for the therapy of CVDs. In particular, we analyze the biological properties of MSCs, elucidate recent clinical findings and clinical trial phases of investigation, highlight clinical therapeutic effects of MSCs, and discuss challenges towards the clinical use of these cells in the therapy of CVDs. |
| format | Article |
| id | doaj-art-e0524302f6624214acef52aa75e6236d |
| institution | OA Journals |
| issn | 2392-7674 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-e0524302f6624214acef52aa75e6236d2025-08-20T01:51:23ZengMDPI AGJournal of Mind and Medical Sciences2392-76742021-10-018217919010.22543/7674.82.P179190Therapeutic efficacy of mesenchymal stem cells for cardiovascular diseasesDragana Radoje MiloradovicDragica Radoje PavlovicMiodrag Bozidar StojkovicSanja Bratislav BojicVladislav Bogdan VolarevicMarina Milosav Gazdic JankovicBiljana Tomislav LjujicDespite the improvements in pharmacological and surgical treatments, cardiovascular diseases (CVDs) are the number one cause of death worldwide. During the last two decades, the search for new therapies has been revolutionized with the growing knowledge of stem cell biology. Due to their huge differentiation capacity and paracrine effects, mesenchymal stem cells (MSCs) are a promising tool for the treatment of CVDs. The encouraging outcomes of preclinical studies using MSCs as a treatment for diseased myocardium have set the scene for worldwide clinical trials. In this review, we overview either complete or ongoing clinical trials using MSCs for the therapy of CVDs. In particular, we analyze the biological properties of MSCs, elucidate recent clinical findings and clinical trial phases of investigation, highlight clinical therapeutic effects of MSCs, and discuss challenges towards the clinical use of these cells in the therapy of CVDs.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1280&context=jmmsmesenchymal stem cellsclinical trialcardiovascular diseases |
| spellingShingle | Dragana Radoje Miloradovic Dragica Radoje Pavlovic Miodrag Bozidar Stojkovic Sanja Bratislav Bojic Vladislav Bogdan Volarevic Marina Milosav Gazdic Jankovic Biljana Tomislav Ljujic Therapeutic efficacy of mesenchymal stem cells for cardiovascular diseases Journal of Mind and Medical Sciences mesenchymal stem cells clinical trial cardiovascular diseases |
| title | Therapeutic efficacy of mesenchymal stem cells for cardiovascular diseases |
| title_full | Therapeutic efficacy of mesenchymal stem cells for cardiovascular diseases |
| title_fullStr | Therapeutic efficacy of mesenchymal stem cells for cardiovascular diseases |
| title_full_unstemmed | Therapeutic efficacy of mesenchymal stem cells for cardiovascular diseases |
| title_short | Therapeutic efficacy of mesenchymal stem cells for cardiovascular diseases |
| title_sort | therapeutic efficacy of mesenchymal stem cells for cardiovascular diseases |
| topic | mesenchymal stem cells clinical trial cardiovascular diseases |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1280&context=jmms |
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