Consolidation of cell-ECM adhesion through direct talin-mediated actin linkage is essential for mouse embryonic morphogenesis

Consolidation of cell-ECM adhesion through direct talin-mediated actin linkage is essential for mouse embryonic morphogenesis

Abstract During animal development, cell-ECM adhesion mediated by integrins is required for the assembly and maintenance of tissues and organs. It can either be transient or stable and requires linking integrins to the cytoskeleton. Talin can link integrins to actin either directly through its actin...

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Bibliographic Details
Main Authors: Wenjun Deng, Rosalyn L. Carr, Rhea R. Kaul, Marina Pavlova-Deb, Amanda Haage, Pere Roca-Cusachs, Guy Tanentzapf
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08294-3
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