<i>FCGR2A</i>-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population
Fc gamma receptors (FcγRs) control humoral and cellular immune responses and maintain the immune system balance. Functional polymorphisms of FcγRs, whose prevalence was dependent on ethnic origin, were found to be associated with systemic lupus erythematosus (SLE) or kidney injuries in several ethni...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/47/7/490 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850078293815984128 |
|---|---|
| author | Fatima Radouani Christophe Deligny Raymond Cesaire Maryvonne Dueymes Georges Dos Santos |
| author_facet | Fatima Radouani Christophe Deligny Raymond Cesaire Maryvonne Dueymes Georges Dos Santos |
| author_sort | Fatima Radouani |
| collection | DOAJ |
| description | Fc gamma receptors (FcγRs) control humoral and cellular immune responses and maintain the immune system balance. Functional polymorphisms of FcγRs, whose prevalence was dependent on ethnic origin, were found to be associated with systemic lupus erythematosus (SLE) or kidney injuries in several ethnic groups. We aimed at investigating the association between the functional single-nucleotide polymorphisms (SNPs) of FcγRIIa-H131R (rs1801274), FcγRIIb-I232T (rs1050501), FcγRIIIa-V158F (rs396991) and FcγRIIIb variants (NA1 and NA2) and lupus erythematosus systemic in an indigenous African Caribbean population. We compared the frequencies of the functional SNPs of <i>FCGR2A</i> (FcγRIIa-H131R, rs1801274), <i>FCGR2B</i> (FcγRIIb-I232T, rs1050501), <i>FCGR3A</i> (FcγRIIIa-V158F, rs396991) and <i>FCGR3B</i> variants (FcγRIIIb NA1 and NA2) between lupus and healthy controls in an indigenous African Caribbean population. We highlighted an association between the <i>FCGR3B</i>-NA1/NA1 and <i>FCGR3A</i>-158F alleles and systemic lupus erythematosus, in addition to an association between <i>FCGR2A</i>-131R and lupus nephritis. Furthermore, an increase in the 131R-158V haplotype in lupus nephritis (30.4%) vs. lupus non-nephritis (15.8%) was noticed. Surprisingly, in spite of the high frequency of the <i>FCGR2B</i>-232T allele in our population, our study did not highlight any association of this allele either with SLE or lupus nephritis (a severe and frequent form of SLE). CD72-Hap1, which has been shown to confer resistance to SLE against T232 allele, was not enhanced in the control group. Our results emphasize an association between <i>FCGR2A</i>-131R and lupus nephritis with a distinctive <i>FCGR</i> polymorphism distribution in an indigenous African Caribbean population, confirming the important variation in the <i>FCGR</i> locus depending on ethnic origin. |
| format | Article |
| id | doaj-art-e04d7901b2ac4f8ba501def1411891ea |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-e04d7901b2ac4f8ba501def1411891ea2025-08-20T02:45:34ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-06-0147749010.3390/cimb47070490<i>FCGR2A</i>-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean PopulationFatima Radouani0Christophe Deligny1Raymond Cesaire2Maryvonne Dueymes3Georges Dos Santos4Laboratory of Immunology, University Hospital of Martinique (CHU Martinique), 97200 Fort de France, FranceDepartment of Internal Medicine, University Hospital of Martinique (CHU Martinique), 97200 Fort de France, FranceDepartment of Virology, University Hospital of Martinique (CHU Martinique), 97200 Fort de France, FranceLaboratory of Immunology, University Hospital of Martinique (CHU Martinique), 97200 Fort de France, FranceLaboratory of Immunology, University Hospital of Martinique (CHU Martinique), 97200 Fort de France, FranceFc gamma receptors (FcγRs) control humoral and cellular immune responses and maintain the immune system balance. Functional polymorphisms of FcγRs, whose prevalence was dependent on ethnic origin, were found to be associated with systemic lupus erythematosus (SLE) or kidney injuries in several ethnic groups. We aimed at investigating the association between the functional single-nucleotide polymorphisms (SNPs) of FcγRIIa-H131R (rs1801274), FcγRIIb-I232T (rs1050501), FcγRIIIa-V158F (rs396991) and FcγRIIIb variants (NA1 and NA2) and lupus erythematosus systemic in an indigenous African Caribbean population. We compared the frequencies of the functional SNPs of <i>FCGR2A</i> (FcγRIIa-H131R, rs1801274), <i>FCGR2B</i> (FcγRIIb-I232T, rs1050501), <i>FCGR3A</i> (FcγRIIIa-V158F, rs396991) and <i>FCGR3B</i> variants (FcγRIIIb NA1 and NA2) between lupus and healthy controls in an indigenous African Caribbean population. We highlighted an association between the <i>FCGR3B</i>-NA1/NA1 and <i>FCGR3A</i>-158F alleles and systemic lupus erythematosus, in addition to an association between <i>FCGR2A</i>-131R and lupus nephritis. Furthermore, an increase in the 131R-158V haplotype in lupus nephritis (30.4%) vs. lupus non-nephritis (15.8%) was noticed. Surprisingly, in spite of the high frequency of the <i>FCGR2B</i>-232T allele in our population, our study did not highlight any association of this allele either with SLE or lupus nephritis (a severe and frequent form of SLE). CD72-Hap1, which has been shown to confer resistance to SLE against T232 allele, was not enhanced in the control group. Our results emphasize an association between <i>FCGR2A</i>-131R and lupus nephritis with a distinctive <i>FCGR</i> polymorphism distribution in an indigenous African Caribbean population, confirming the important variation in the <i>FCGR</i> locus depending on ethnic origin.https://www.mdpi.com/1467-3045/47/7/490FcγRs polymorphismssystemic lupus erythematosusAfrican Caribbeanlupus nephritis |
| spellingShingle | Fatima Radouani Christophe Deligny Raymond Cesaire Maryvonne Dueymes Georges Dos Santos <i>FCGR2A</i>-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population Current Issues in Molecular Biology FcγRs polymorphisms systemic lupus erythematosus African Caribbean lupus nephritis |
| title | <i>FCGR2A</i>-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population |
| title_full | <i>FCGR2A</i>-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population |
| title_fullStr | <i>FCGR2A</i>-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population |
| title_full_unstemmed | <i>FCGR2A</i>-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population |
| title_short | <i>FCGR2A</i>-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population |
| title_sort | i fcgr2a i 131r is associated with lupus nephritis rather than non lupus nephritis sle in an indigenous african caribbean population |
| topic | FcγRs polymorphisms systemic lupus erythematosus African Caribbean lupus nephritis |
| url | https://www.mdpi.com/1467-3045/47/7/490 |
| work_keys_str_mv | AT fatimaradouani ifcgr2ai131risassociatedwithlupusnephritisratherthannonlupusnephritissleinanindigenousafricancaribbeanpopulation AT christophedeligny ifcgr2ai131risassociatedwithlupusnephritisratherthannonlupusnephritissleinanindigenousafricancaribbeanpopulation AT raymondcesaire ifcgr2ai131risassociatedwithlupusnephritisratherthannonlupusnephritissleinanindigenousafricancaribbeanpopulation AT maryvonnedueymes ifcgr2ai131risassociatedwithlupusnephritisratherthannonlupusnephritissleinanindigenousafricancaribbeanpopulation AT georgesdossantos ifcgr2ai131risassociatedwithlupusnephritisratherthannonlupusnephritissleinanindigenousafricancaribbeanpopulation |