Efficacy analysis of 5-aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing age
Objective To investigate the efficacy and long-term durability of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating vulvar lichen sclerosus (VLS) in women of childbearing age.Methods Fifty-five patients with VLS who had failed long-term repeated pharmacological treatments (mean diseas...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2025.2497362 |
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| author | Lijuan Yang Qian Shang Dongning Zhu Yu Jia Chunyu Shi Yanling Dang |
| author_facet | Lijuan Yang Qian Shang Dongning Zhu Yu Jia Chunyu Shi Yanling Dang |
| author_sort | Lijuan Yang |
| collection | DOAJ |
| description | Objective To investigate the efficacy and long-term durability of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating vulvar lichen sclerosus (VLS) in women of childbearing age.Methods Fifty-five patients with VLS who had failed long-term repeated pharmacological treatments (mean disease duration: 3.6 ± 1.4 years)were enrolled. All participants underwent four sessions of ALA-PDT. Follow-up evaluations were conducted for six months after treatment. Outcomes were assessed using the Cattaneo clinical symptom and sign score and the Dermatology Life Quality Index (DLQI) questionnaire at baseline, after four treatments, and at 3–6 months post-treatment.Results At the 6-month follow-up, efficacy rates were 81.8% for pruritus relief, 67.3% for skin elasticity restoration, 63.6% for skin color improvement, and 72.7% for lesion area reduction. Pain was the only reported adverse reaction during treatment.Conclusion 20% ALA-PDT is a safe, effective, and durable therapeutic option for VLS with minimal side effects. Notably, it provides a viable alternative for patients unresponsive to conventional therapies. |
| format | Article |
| id | doaj-art-e04c5f4940424e289fa8829ef5635f40 |
| institution | Kabale University |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-e04c5f4940424e289fa8829ef5635f402025-08-20T03:52:32ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532025-12-0136110.1080/09546634.2025.2497362Efficacy analysis of 5-aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing ageLijuan Yang0Qian Shang1Dongning Zhu2Yu Jia3Chunyu Shi4Yanling Dang5Department of Dermatology, Northwest Women and Children’s Hospital, Shaanxi, Xi’an, ChinaDepartment of Dermatology, Northwest Women and Children’s Hospital, Shaanxi, Xi’an, ChinaDepartment of Dermatology, Northwest Women and Children’s Hospital, Shaanxi, Xi’an, ChinaDepartment of Dermatology, Northwest Women and Children’s Hospital, Shaanxi, Xi’an, ChinaDepartment of Dermatology, Northwest Women and Children’s Hospital, Shaanxi, Xi’an, ChinaDepartment of Dermatology, Northwest Women and Children’s Hospital, Shaanxi, Xi’an, ChinaObjective To investigate the efficacy and long-term durability of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating vulvar lichen sclerosus (VLS) in women of childbearing age.Methods Fifty-five patients with VLS who had failed long-term repeated pharmacological treatments (mean disease duration: 3.6 ± 1.4 years)were enrolled. All participants underwent four sessions of ALA-PDT. Follow-up evaluations were conducted for six months after treatment. Outcomes were assessed using the Cattaneo clinical symptom and sign score and the Dermatology Life Quality Index (DLQI) questionnaire at baseline, after four treatments, and at 3–6 months post-treatment.Results At the 6-month follow-up, efficacy rates were 81.8% for pruritus relief, 67.3% for skin elasticity restoration, 63.6% for skin color improvement, and 72.7% for lesion area reduction. Pain was the only reported adverse reaction during treatment.Conclusion 20% ALA-PDT is a safe, effective, and durable therapeutic option for VLS with minimal side effects. Notably, it provides a viable alternative for patients unresponsive to conventional therapies.https://www.tandfonline.com/doi/10.1080/09546634.2025.2497362Vulvar lichen sclerosusphotodynamic therapy5-aminolevulinic acid |
| spellingShingle | Lijuan Yang Qian Shang Dongning Zhu Yu Jia Chunyu Shi Yanling Dang Efficacy analysis of 5-aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing age Journal of Dermatological Treatment Vulvar lichen sclerosus photodynamic therapy 5-aminolevulinic acid |
| title | Efficacy analysis of 5-aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing age |
| title_full | Efficacy analysis of 5-aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing age |
| title_fullStr | Efficacy analysis of 5-aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing age |
| title_full_unstemmed | Efficacy analysis of 5-aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing age |
| title_short | Efficacy analysis of 5-aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing age |
| title_sort | efficacy analysis of 5 aminolevulinic acid photodynamic therapy for vulvar lichen sclerosus in women of childbearing age |
| topic | Vulvar lichen sclerosus photodynamic therapy 5-aminolevulinic acid |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2025.2497362 |
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