Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies
The development of multidrug resistance (MDR) and subsequent relapse on therapy is a widespread problem in breast cancer, but our understanding of the underlying molecular mechanisms is incomplete. Numerous studies have aimed to establish the role of drug transporter pumps in MDR and to link their e...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.4061/2011/967419 |
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| _version_ | 1850166408492613632 |
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| author | N. S. Wind I. Holen |
| author_facet | N. S. Wind I. Holen |
| author_sort | N. S. Wind |
| collection | DOAJ |
| description | The development of multidrug resistance (MDR) and subsequent relapse on therapy is a widespread problem in breast cancer, but our understanding of the underlying molecular mechanisms is incomplete. Numerous studies have aimed to establish the role of drug transporter pumps in MDR and to link their expression to response to chemotherapy. The ATP-binding cassette (ABC) transporters are central to breast cancer MDR, and increases in ABC expression levels have been shown to correlate with decreases in response to various chemotherapy drugs and a reduction in overall survival. But as there is a large degree of redundancy between different ABC transporters, this correlation has not been seen in all studies. This paper provides an introduction to the key molecules associated with breast cancer MDR and summarises evidence of their potential roles reported from model systems and clinical studies. We provide possible explanations for why despite several decades of research, the precise role of ABC transporters in breast cancer MDR remains elusive. |
| format | Article |
| id | doaj-art-e04b88782f474c608b3297e576b91e86 |
| institution | OA Journals |
| issn | 2090-3189 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-e04b88782f474c608b3297e576b91e862025-08-20T02:21:28ZengWileyInternational Journal of Breast Cancer2090-31892011-01-01201110.4061/2011/967419967419Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical StudiesN. S. Wind0I. Holen1Academic Unit of Clinical Oncology, DU10, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UKAcademic Unit of Clinical Oncology, DU10, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UKThe development of multidrug resistance (MDR) and subsequent relapse on therapy is a widespread problem in breast cancer, but our understanding of the underlying molecular mechanisms is incomplete. Numerous studies have aimed to establish the role of drug transporter pumps in MDR and to link their expression to response to chemotherapy. The ATP-binding cassette (ABC) transporters are central to breast cancer MDR, and increases in ABC expression levels have been shown to correlate with decreases in response to various chemotherapy drugs and a reduction in overall survival. But as there is a large degree of redundancy between different ABC transporters, this correlation has not been seen in all studies. This paper provides an introduction to the key molecules associated with breast cancer MDR and summarises evidence of their potential roles reported from model systems and clinical studies. We provide possible explanations for why despite several decades of research, the precise role of ABC transporters in breast cancer MDR remains elusive.http://dx.doi.org/10.4061/2011/967419 |
| spellingShingle | N. S. Wind I. Holen Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies International Journal of Breast Cancer |
| title | Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies |
| title_full | Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies |
| title_fullStr | Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies |
| title_full_unstemmed | Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies |
| title_short | Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies |
| title_sort | multidrug resistance in breast cancer from in vitro models to clinical studies |
| url | http://dx.doi.org/10.4061/2011/967419 |
| work_keys_str_mv | AT nswind multidrugresistanceinbreastcancerfrominvitromodelstoclinicalstudies AT iholen multidrugresistanceinbreastcancerfrominvitromodelstoclinicalstudies |