NPS-2143 suppresses malignant phenotypes of retinoblastoma cells involved in regulating NF-κB pathway

NPS-2143 suppresses malignant phenotypes of retinoblastoma cells involved in regulating NF-κB pathway

Abstract NPS-2143, as a CaSR allosteric antagonist, performs an important role in diverse cancers. However, the function and mechanism of NPS-2143 in human retinoblastoma have not been reported. Cell viability was evaluated by using cell counting kit-8, flow cytometry was used for apoptosis detectio...

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Bibliographic Details
Main Authors: Cuiying Zhang, Tao Yu, Guanghua Sun, Miao Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
NPS-2143
Proliferation
Apoptosis
NF-κB
Online Access:https://doi.org/10.1038/s41598-025-00783-z
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