Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB
Background: Breast cancer cells can develop chemoresistance after prolonged exposure to cytotoxic drugs due to expression of the multi drug resistance (MDR) 1 gene. Type 2 cyclo-oxygenase (COX-2) inhibitors reverse the chemoresistance phenotype of a medullary thyroid carcinoma cell line, TT, and of...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0490 |
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| _version_ | 1849691784515420160 |
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| author | Maria Chiara Zatelli Daniela Molè Federico Tagliati Mariella Minoia Maria Rosaria Ambrosio Ettore Degli Uberti |
| author_facet | Maria Chiara Zatelli Daniela Molè Federico Tagliati Mariella Minoia Maria Rosaria Ambrosio Ettore Degli Uberti |
| author_sort | Maria Chiara Zatelli |
| collection | DOAJ |
| description | Background: Breast cancer cells can develop chemoresistance after prolonged exposure to cytotoxic drugs due to expression of the multi drug resistance (MDR) 1 gene. Type 2 cyclo-oxygenase (COX-2) inhibitors reverse the chemoresistance phenotype of a medullary thyroid carcinoma cell line, TT, and of a breast cancer cell line, MCF7, by inhibiting MDR1 expression and P-gp function. |
| format | Article |
| id | doaj-art-e0450d1c8ea648b998382daa483a8bf3 |
| institution | DOAJ |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-e0450d1c8ea648b998382daa483a8bf32025-08-20T03:20:56ZengWileyCellular Oncology1570-58701875-86062009-01-0131645746510.3233/CLO-2009-0490Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κBMaria Chiara Zatelli0Daniela Molè1Federico Tagliati2Mariella Minoia3Maria Rosaria Ambrosio4Ettore Degli Uberti5Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, ItalySection of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, ItalySection of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, ItalySection of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, ItalySection of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, ItalySection of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, ItalyBackground: Breast cancer cells can develop chemoresistance after prolonged exposure to cytotoxic drugs due to expression of the multi drug resistance (MDR) 1 gene. Type 2 cyclo-oxygenase (COX-2) inhibitors reverse the chemoresistance phenotype of a medullary thyroid carcinoma cell line, TT, and of a breast cancer cell line, MCF7, by inhibiting MDR1 expression and P-gp function.http://dx.doi.org/10.3233/CLO-2009-0490 |
| spellingShingle | Maria Chiara Zatelli Daniela Molè Federico Tagliati Mariella Minoia Maria Rosaria Ambrosio Ettore Degli Uberti Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB Cellular Oncology |
| title | Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB |
| title_full | Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB |
| title_fullStr | Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB |
| title_full_unstemmed | Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB |
| title_short | Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB |
| title_sort | cyclo oxygenase 2 modulates chemoresistance in breast cancer cells involving nf κb |
| url | http://dx.doi.org/10.3233/CLO-2009-0490 |
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