Thapsigargin triggers a non-apoptotic, caspase-independent programmed cell death in basophilic leukaemia cells
Abstract Thapsigargin (TG), a potent inhibitor of the sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA), is widely used to study intracellular Ca²⁺ homeostasis and has shown—along prodrug derivatives—promise as an anticancer agent. While TG is traditionally considered an inducer of apoptosis, the prec...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02602-w |
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