Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery?
Taurolidine, known for its broad-spectrum antimicrobial properties and low toxicity, has shown promise in reducing infections in various surgical settings. However, it has not been extensively evaluated in orthopedic surgery. This study assessed the efficacy of taurolidine irrigation in reducing sur...
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MDPI AG
2024-09-01
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| Series: | Antibiotics |
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| author | Shubham Yashwant Dakhode Woo Sub Kim Hyun Jin Kim Seung Yeol Lee |
| author_facet | Shubham Yashwant Dakhode Woo Sub Kim Hyun Jin Kim Seung Yeol Lee |
| author_sort | Shubham Yashwant Dakhode |
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| description | Taurolidine, known for its broad-spectrum antimicrobial properties and low toxicity, has shown promise in reducing infections in various surgical settings. However, it has not been extensively evaluated in orthopedic surgery. This study assessed the efficacy of taurolidine irrigation in reducing surgical site infections in patients undergoing ankle fracture surgery. A retrospective review was conducted for patients >20 years old who underwent ankle fracture surgery between March 2016 and March 2023, with follow-ups exceeding 6 months. Patients were classified into the following two groups: those who underwent normal saline (NS) irrigation and those who underwent taurolidine irrigation. Minor infections were defined as requiring additional oral antibiotics postoperatively, while major infections were characterized by hospitalization or reoperation due to infection within 3 months. Of 844 patients, 688 were included. The taurolidine group (<i>n</i> = 328) had a significant reduction in minor infections (7.3% vs. 22.5%, odds ratio = 0.410, <i>p</i> = 0.028) compared to the NS group (<i>n</i> = 360). Major infections were fewer in the NS group (1.2% vs. 0%, <i>p</i> = 0.051), but the number of cases was too small for reliable analysis. Taurolidine irrigation significantly reduces the occurrence of minor infections in ankle fracture surgeries when compared to normal saline irrigation. |
| format | Article |
| id | doaj-art-e0401a1a0dd541cea5cb8d4f0dcc1527 |
| institution | OA Journals |
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| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-e0401a1a0dd541cea5cb8d4f0dcc15272025-08-20T01:56:10ZengMDPI AGAntibiotics2079-63822024-09-0113984110.3390/antibiotics13090841Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery?Shubham Yashwant Dakhode0Woo Sub Kim1Hyun Jin Kim2Seung Yeol Lee3Department of Orthopaedics, District General Hospital, Bhandara 441904, IndiaDepartment of Orthopaedic Surgery, Myongji Hospital, Hanyang University College of Medicine, 55, Hwasu-ro 14beon-gil, Deogyang-gu, Gyeonggi-do, Goyang-si 10475, Republic of KoreaDepartment of Orthopaedic Surgery, Myongji Hospital, Hanyang University College of Medicine, 55, Hwasu-ro 14beon-gil, Deogyang-gu, Gyeonggi-do, Goyang-si 10475, Republic of KoreaDepartment of Orthopaedic Surgery, Myongji Hospital, Hanyang University College of Medicine, 55, Hwasu-ro 14beon-gil, Deogyang-gu, Gyeonggi-do, Goyang-si 10475, Republic of KoreaTaurolidine, known for its broad-spectrum antimicrobial properties and low toxicity, has shown promise in reducing infections in various surgical settings. However, it has not been extensively evaluated in orthopedic surgery. This study assessed the efficacy of taurolidine irrigation in reducing surgical site infections in patients undergoing ankle fracture surgery. A retrospective review was conducted for patients >20 years old who underwent ankle fracture surgery between March 2016 and March 2023, with follow-ups exceeding 6 months. Patients were classified into the following two groups: those who underwent normal saline (NS) irrigation and those who underwent taurolidine irrigation. Minor infections were defined as requiring additional oral antibiotics postoperatively, while major infections were characterized by hospitalization or reoperation due to infection within 3 months. Of 844 patients, 688 were included. The taurolidine group (<i>n</i> = 328) had a significant reduction in minor infections (7.3% vs. 22.5%, odds ratio = 0.410, <i>p</i> = 0.028) compared to the NS group (<i>n</i> = 360). Major infections were fewer in the NS group (1.2% vs. 0%, <i>p</i> = 0.051), but the number of cases was too small for reliable analysis. Taurolidine irrigation significantly reduces the occurrence of minor infections in ankle fracture surgeries when compared to normal saline irrigation.https://www.mdpi.com/2079-6382/13/9/841ankle fracturesinfection controlorthopedic proceduressurgical site infectiontaurolidinewound irrigation |
| spellingShingle | Shubham Yashwant Dakhode Woo Sub Kim Hyun Jin Kim Seung Yeol Lee Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery? Antibiotics ankle fractures infection control orthopedic procedures surgical site infection taurolidine wound irrigation |
| title | Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery? |
| title_full | Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery? |
| title_fullStr | Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery? |
| title_full_unstemmed | Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery? |
| title_short | Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery? |
| title_sort | is taurolidine irrigation effective in preventing surgical site infection during fracture surgery |
| topic | ankle fractures infection control orthopedic procedures surgical site infection taurolidine wound irrigation |
| url | https://www.mdpi.com/2079-6382/13/9/841 |
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