Decoding and designing: Promising routes to tailor-made herbs
Abstract. The ideal characteristics of herbs can be summarized as a high content of secondary metabolites, high stress resistance, desirable shape, and high yield. In this study, 2 strategies are proposed for decoding the biogenesis and quality formation mechanisms of active ingredients and targets...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2025-06-01
|
| Series: | Science of Traditional Chinese Medicine |
| Online Access: | http://journals.lww.com/10.1097/st9.0000000000000065 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849416179663241216 |
|---|---|
| author | Jianwu Shi Yu Wu Lei Zhang |
| author_facet | Jianwu Shi Yu Wu Lei Zhang |
| author_sort | Jianwu Shi |
| collection | DOAJ |
| description | Abstract. The ideal characteristics of herbs can be summarized as a high content of secondary metabolites, high stress resistance, desirable shape, and high yield. In this study, 2 strategies are proposed for decoding the biogenesis and quality formation mechanisms of active ingredients and targets for genetic breeding of yield and resistance in traditional Chinese medicine. First, multiomics can be applied in decoding the synthesis pathways of secondary metabolites and the mechanisms underlying the formation of desirable traits. Second, the identification of molecular markers and target genes associated with desirable traits in ideal herbs can be achieved through Genome-Wide Association Studies. Ideal herbs are further designed through genomic selection and gene editing technologies. These strategies will provide references for the investigation of herb breeding. |
| format | Article |
| id | doaj-art-e040117a24c548d0a3ea386abbc53bdc |
| institution | Kabale University |
| issn | 2836-922X 2836-9211 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Science of Traditional Chinese Medicine |
| spelling | doaj-art-e040117a24c548d0a3ea386abbc53bdc2025-08-20T03:33:15ZengWolters Kluwer Health/LWWScience of Traditional Chinese Medicine2836-922X2836-92112025-06-013219419710.1097/st9.0000000000000065202506000-00010Decoding and designing: Promising routes to tailor-made herbsJianwu Shi0Yu Wu1Lei Zhang2a Institute of Interdisciplinary Integrative Medicine Research, Medical School, Nantong University, Nantong, Chinab Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai, Chinaa Institute of Interdisciplinary Integrative Medicine Research, Medical School, Nantong University, Nantong, ChinaAbstract. The ideal characteristics of herbs can be summarized as a high content of secondary metabolites, high stress resistance, desirable shape, and high yield. In this study, 2 strategies are proposed for decoding the biogenesis and quality formation mechanisms of active ingredients and targets for genetic breeding of yield and resistance in traditional Chinese medicine. First, multiomics can be applied in decoding the synthesis pathways of secondary metabolites and the mechanisms underlying the formation of desirable traits. Second, the identification of molecular markers and target genes associated with desirable traits in ideal herbs can be achieved through Genome-Wide Association Studies. Ideal herbs are further designed through genomic selection and gene editing technologies. These strategies will provide references for the investigation of herb breeding.http://journals.lww.com/10.1097/st9.0000000000000065 |
| spellingShingle | Jianwu Shi Yu Wu Lei Zhang Decoding and designing: Promising routes to tailor-made herbs Science of Traditional Chinese Medicine |
| title | Decoding and designing: Promising routes to tailor-made herbs |
| title_full | Decoding and designing: Promising routes to tailor-made herbs |
| title_fullStr | Decoding and designing: Promising routes to tailor-made herbs |
| title_full_unstemmed | Decoding and designing: Promising routes to tailor-made herbs |
| title_short | Decoding and designing: Promising routes to tailor-made herbs |
| title_sort | decoding and designing promising routes to tailor made herbs |
| url | http://journals.lww.com/10.1097/st9.0000000000000065 |
| work_keys_str_mv | AT jianwushi decodinganddesigningpromisingroutestotailormadeherbs AT yuwu decodinganddesigningpromisingroutestotailormadeherbs AT leizhang decodinganddesigningpromisingroutestotailormadeherbs |