Comment on: “Atom‐Modified gDNA Enhances Cleavage Activity of TtAgo Enabling Ultrasensitive Nucleic Acid Testing”

Comment on: “Atom‐Modified gDNA Enhances Cleavage Activity of TtAgo Enabling Ultrasensitive Nucleic Acid Testing”

Abstract The recent article by Zhang et al. piqued the interest. An atom‐modification‐based strategy is reported to enhance the cleavage activity of TtAgo, improving its practicability in TtAgo‐based nucleic acid testing. Specifically, the 2′‐fluorine (2′F)‐modified guide DNA (2′F‐gDNA) shows signif...

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Bibliographic Details
Main Authors: Yue Tang, Xiao‐han Wang, Xu Xu, Lu‐sheng Xin, Xiu‐dan Wang, Xin‐min Li
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
2'‐fluorine modified gDNA
dsDNA cleavage
gene editing
nucleic acid detection
TtAgo
Online Access:https://doi.org/10.1002/advs.202406872
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