TRAP1 functions in the morphogenesis of the embryonic kidney
TNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology with a cytosolic chaperon HSP90. It has been shown that TRAP1 functions as an inhibitor for apoptosis by preventing cytochrome-c release from mitochondria. In addition, TRAP1 seems to play critical role...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Animal Cells and Systems |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2025.2477789 |
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| author | Ha Eun Kim Taejoon Kwon Hyo Jung Sim Tae Joo Park |
| author_facet | Ha Eun Kim Taejoon Kwon Hyo Jung Sim Tae Joo Park |
| author_sort | Ha Eun Kim |
| collection | DOAJ |
| description | TNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology with a cytosolic chaperon HSP90. It has been shown that TRAP1 functions as an inhibitor for apoptosis by preventing cytochrome-c release from mitochondria. In addition, TRAP1 seems to play critical roles in metabolic processes for energy production, such as glycolysis and β-oxidation. It has also been reported that TRAP1 is a direct target of PTEN-induced kinase 1 (PINK1) and may be a cause of Parkinson’s disease (PD) in humans. Although the biochemical functions of TRAP1 are under intense study for the physiology and treatment of various cancers, its roles in vertebrate development have not been reported. This study shows that Xenopus TRAP1 is strongly expressed in the developing muscle, kidney, and brain tissues. Perturbation of TRAP1 function by treating TRAP1 inhibiter GTPP or microinjection of antisense-morpholino oligo (MO) caused mild defects in striated muscle fiber formation. Furthermore, the looping patterns of developing kidney tubules were perturbed, indicating that TRAP1 function is necessary for proper kidney development. |
| format | Article |
| id | doaj-art-e03d462f8e9d4815b35073bf1f2e35a3 |
| institution | DOAJ |
| issn | 1976-8354 2151-2485 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj-art-e03d462f8e9d4815b35073bf1f2e35a32025-08-20T03:05:41ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852025-12-0129119120010.1080/19768354.2025.2477789TRAP1 functions in the morphogenesis of the embryonic kidneyHa Eun Kim0Taejoon Kwon1Hyo Jung Sim2Tae Joo Park3Department of Biological Sciences, College of Infaormation-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of KoreaDepartment of Biomedical Engineering, College of Information-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of KoreaDepartment of Biological Sciences, College of Infaormation-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of KoreaDepartment of Biological Sciences, College of Infaormation-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of KoreaTNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology with a cytosolic chaperon HSP90. It has been shown that TRAP1 functions as an inhibitor for apoptosis by preventing cytochrome-c release from mitochondria. In addition, TRAP1 seems to play critical roles in metabolic processes for energy production, such as glycolysis and β-oxidation. It has also been reported that TRAP1 is a direct target of PTEN-induced kinase 1 (PINK1) and may be a cause of Parkinson’s disease (PD) in humans. Although the biochemical functions of TRAP1 are under intense study for the physiology and treatment of various cancers, its roles in vertebrate development have not been reported. This study shows that Xenopus TRAP1 is strongly expressed in the developing muscle, kidney, and brain tissues. Perturbation of TRAP1 function by treating TRAP1 inhibiter GTPP or microinjection of antisense-morpholino oligo (MO) caused mild defects in striated muscle fiber formation. Furthermore, the looping patterns of developing kidney tubules were perturbed, indicating that TRAP1 function is necessary for proper kidney development.https://www.tandfonline.com/doi/10.1080/19768354.2025.2477789TRAP1kidneymuscleXenopus |
| spellingShingle | Ha Eun Kim Taejoon Kwon Hyo Jung Sim Tae Joo Park TRAP1 functions in the morphogenesis of the embryonic kidney Animal Cells and Systems TRAP1 kidney muscle Xenopus |
| title | TRAP1 functions in the morphogenesis of the embryonic kidney |
| title_full | TRAP1 functions in the morphogenesis of the embryonic kidney |
| title_fullStr | TRAP1 functions in the morphogenesis of the embryonic kidney |
| title_full_unstemmed | TRAP1 functions in the morphogenesis of the embryonic kidney |
| title_short | TRAP1 functions in the morphogenesis of the embryonic kidney |
| title_sort | trap1 functions in the morphogenesis of the embryonic kidney |
| topic | TRAP1 kidney muscle Xenopus |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2025.2477789 |
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