High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema
<b>Background/Objectives</b>: Accurate diagnosis of breast cancer-related lymphedema remains a clinical challenge. This study evaluated the diagnostic utility of ultrasound in detecting early lymphedema compared to conventional criteria, including the International Society of Lymphology...
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2025-06-01
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| author | Ivana Klarić-Kukuz Danijela Budimir Mršić Antonela Matana Blaž Barun Jure Aljinović Maja Marinović-Guić Ana Poljičanin |
| author_facet | Ivana Klarić-Kukuz Danijela Budimir Mršić Antonela Matana Blaž Barun Jure Aljinović Maja Marinović-Guić Ana Poljičanin |
| author_sort | Ivana Klarić-Kukuz |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Accurate diagnosis of breast cancer-related lymphedema remains a clinical challenge. This study evaluated the diagnostic utility of ultrasound in detecting early lymphedema compared to conventional criteria, including the International Society of Lymphology staging and limb volume measurements. <b>Methods</b>: In this retrospective cross-sectional study, 68 female participants with unilateral breast cancer, who had completed cancer treatment at least six months before study enrolment, underwent both ultrasonographic assessment and standard limb circumference measurements. Ultrasound was performed bilaterally at five standardized anatomical sites. Sonographic parameters included assessment of cutaneous and subcutaneous thickness and echogenicity. Clinical staging and symptom profiles were assessed using ISL criteria and a structured questionnaire. Volume status was determined by relative volume change (RVC). <b>Results</b>: Among 68 participants, 36 were classified as ISL stage 0 and 32 as ISL stage II, 30 had RVC < 5%, while 38 had RVC ≥ 5%. Advanced stages were associated with older age. Multivariate analysis identified increased skin thickness at the medial upper arm cutis as significantly correlated with RVC ≥ 5% (OR 1.49, 95% CI: 1.01–2.21, <i>p</i> = 0.047). A similar trend was observed at the medial forearm (OR 1.3 (95% CI: (0.99, 1.71))). <b>Conclusions</b>: This study highlights ultrasound’s potential for early breast cancer-related lymphedema detection, especially in patients with minimal volume changes where conventional methods fall short. Increased cutaneous thickness in the medial upper arm emerged as a sensitive marker of early disease, while subcutaneous thickness and echogenicity may reflect in advanced stages. This distinction underscores the clinical value of cutaneous thickness as a potential clinical key marker for early lymphedema detection, emphasizing the need for standardized protocols and defined thresholds to guide timely interventions. |
| format | Article |
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| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-e03be7eeb76648ef88ffe7c643f0e0532025-08-20T03:27:18ZengMDPI AGBiomedicines2227-90592025-06-01136139610.3390/biomedicines13061396High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related LymphedemaIvana Klarić-Kukuz0Danijela Budimir Mršić1Antonela Matana2Blaž Barun3Jure Aljinović4Maja Marinović-Guić5Ana Poljičanin6Department of Health Studies, University of Split, 21000 Split, CroatiaDepartment of Health Studies, University of Split, 21000 Split, CroatiaDepartment of Health Studies, University of Split, 21000 Split, CroatiaInstitute of Physical Medicine and Rehabilitation with Rheumatology, University Hospital of Split, 21000 Split, CroatiaDepartment of Health Studies, University of Split, 21000 Split, CroatiaDepartment of Health Studies, University of Split, 21000 Split, CroatiaDepartment of Health Studies, University of Split, 21000 Split, Croatia<b>Background/Objectives</b>: Accurate diagnosis of breast cancer-related lymphedema remains a clinical challenge. This study evaluated the diagnostic utility of ultrasound in detecting early lymphedema compared to conventional criteria, including the International Society of Lymphology staging and limb volume measurements. <b>Methods</b>: In this retrospective cross-sectional study, 68 female participants with unilateral breast cancer, who had completed cancer treatment at least six months before study enrolment, underwent both ultrasonographic assessment and standard limb circumference measurements. Ultrasound was performed bilaterally at five standardized anatomical sites. Sonographic parameters included assessment of cutaneous and subcutaneous thickness and echogenicity. Clinical staging and symptom profiles were assessed using ISL criteria and a structured questionnaire. Volume status was determined by relative volume change (RVC). <b>Results</b>: Among 68 participants, 36 were classified as ISL stage 0 and 32 as ISL stage II, 30 had RVC < 5%, while 38 had RVC ≥ 5%. Advanced stages were associated with older age. Multivariate analysis identified increased skin thickness at the medial upper arm cutis as significantly correlated with RVC ≥ 5% (OR 1.49, 95% CI: 1.01–2.21, <i>p</i> = 0.047). A similar trend was observed at the medial forearm (OR 1.3 (95% CI: (0.99, 1.71))). <b>Conclusions</b>: This study highlights ultrasound’s potential for early breast cancer-related lymphedema detection, especially in patients with minimal volume changes where conventional methods fall short. Increased cutaneous thickness in the medial upper arm emerged as a sensitive marker of early disease, while subcutaneous thickness and echogenicity may reflect in advanced stages. This distinction underscores the clinical value of cutaneous thickness as a potential clinical key marker for early lymphedema detection, emphasizing the need for standardized protocols and defined thresholds to guide timely interventions.https://www.mdpi.com/2227-9059/13/6/1396lymphedemabreast cancerdiagnostic ultrasoundcross-sectional anatomydisease early detection |
| spellingShingle | Ivana Klarić-Kukuz Danijela Budimir Mršić Antonela Matana Blaž Barun Jure Aljinović Maja Marinović-Guić Ana Poljičanin High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema Biomedicines lymphedema breast cancer diagnostic ultrasound cross-sectional anatomy disease early detection |
| title | High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema |
| title_full | High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema |
| title_fullStr | High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema |
| title_full_unstemmed | High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema |
| title_short | High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema |
| title_sort | high frequency ultrasonography imaging anatomical measuring site as potential clinical marker for early identification of breast cancer related lymphedema |
| topic | lymphedema breast cancer diagnostic ultrasound cross-sectional anatomy disease early detection |
| url | https://www.mdpi.com/2227-9059/13/6/1396 |
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