Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study
Introduction Esophageal varices (EV) are dilated submucosal veins in the distal esophagus connecting the portal vein to the systemic circulation. Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease associated with a variety of cardiovascular and peripheral vascular diseases. The aim of t...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-07-01
|
| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Association-between-type-1-diabetes-mellitus-and-esophageal-varices-a-Mendelian-randomization,191419,0,2.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850032666037977088 |
|---|---|
| author | Kai Feng Jiang Yuan Yanhui Wei Min Li |
| author_facet | Kai Feng Jiang Yuan Yanhui Wei Min Li |
| author_sort | Kai Feng |
| collection | DOAJ |
| description | Introduction
Esophageal varices (EV) are dilated submucosal veins in the distal esophagus connecting the portal vein to the systemic circulation. Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease associated with a variety of cardiovascular and peripheral vascular diseases. The aim of this study was to investigate the causal relationship between T1DM and EV from a genetic perspective.
Material and methods
We performed a genome-wide association study of the causal relationship between T1DM and EV using pooled data from the GWAS database. Firstly, we conducted a two-sample Mendelian randomization (MR) study of these two diseases. Next, we used multivariate Mendelian randomization (MVMR) to further confirm the effect of type 1 diabetes on esophageal varices after excluding confounding factors such as cirrhosis and immune system disorders associated with type 1 diabetes mellitus. Sensitivity analyses were performed using Cochran’s Q test, MR-Egger intercept, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) methods, leave-one-out analysis and funnel plots.
Results
In all two-sample MR analyses, the p -values of the IVW were all 1, and the directions of the IVW and MR-Egger assays were consistent. No horizontal pleiotropy was found for the MR-Egger intercept, and leave-one out analysis showed that the results remained stable after the removal of individual SNPs. MVMR analysis showed that the causal relationship between type 1 diabetes mellitus and esophageal varices persisted after exclusion of immune-related confounders.
Conclusions
The results of the MR analysis supported a causal relationship between T1DM and EV risk. |
| format | Article |
| id | doaj-art-e039802012b141798b1f16492e13d6d2 |
| institution | DOAJ |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-e039802012b141798b1f16492e13d6d22025-08-20T02:58:33ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-07-0121260561610.5114/aoms/191419191419Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization studyKai Feng0Jiang Yuan1Yanhui Wei2Min Li3Thoracic Surgery Department, Binzhou People’s Hospital, Binzhou, ChinaThoracic Surgery Department, Binzhou People’s Hospital, Binzhou, ChinaPharmacy Department, Binzhou People’s Hospital, Binzhou, ChinaDepartment of Ultrasound Medicine, Binzhou Medical University Hospital, Binzhou, ChinaIntroduction Esophageal varices (EV) are dilated submucosal veins in the distal esophagus connecting the portal vein to the systemic circulation. Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease associated with a variety of cardiovascular and peripheral vascular diseases. The aim of this study was to investigate the causal relationship between T1DM and EV from a genetic perspective. Material and methods We performed a genome-wide association study of the causal relationship between T1DM and EV using pooled data from the GWAS database. Firstly, we conducted a two-sample Mendelian randomization (MR) study of these two diseases. Next, we used multivariate Mendelian randomization (MVMR) to further confirm the effect of type 1 diabetes on esophageal varices after excluding confounding factors such as cirrhosis and immune system disorders associated with type 1 diabetes mellitus. Sensitivity analyses were performed using Cochran’s Q test, MR-Egger intercept, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) methods, leave-one-out analysis and funnel plots. Results In all two-sample MR analyses, the p -values of the IVW were all 1, and the directions of the IVW and MR-Egger assays were consistent. No horizontal pleiotropy was found for the MR-Egger intercept, and leave-one out analysis showed that the results remained stable after the removal of individual SNPs. MVMR analysis showed that the causal relationship between type 1 diabetes mellitus and esophageal varices persisted after exclusion of immune-related confounders. Conclusions The results of the MR analysis supported a causal relationship between T1DM and EV risk.https://www.archivesofmedicalscience.com/Association-between-type-1-diabetes-mellitus-and-esophageal-varices-a-Mendelian-randomization,191419,0,2.htmlesophageal varicestype 1 diabetes mellitusmendelian randomizationmultivariate mendelian randomization |
| spellingShingle | Kai Feng Jiang Yuan Yanhui Wei Min Li Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study Archives of Medical Science esophageal varices type 1 diabetes mellitus mendelian randomization multivariate mendelian randomization |
| title | Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study |
| title_full | Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study |
| title_fullStr | Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study |
| title_full_unstemmed | Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study |
| title_short | Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study |
| title_sort | association between type 1 diabetes mellitus and esophageal varices a mendelian randomization study |
| topic | esophageal varices type 1 diabetes mellitus mendelian randomization multivariate mendelian randomization |
| url | https://www.archivesofmedicalscience.com/Association-between-type-1-diabetes-mellitus-and-esophageal-varices-a-Mendelian-randomization,191419,0,2.html |
| work_keys_str_mv | AT kaifeng associationbetweentype1diabetesmellitusandesophagealvaricesamendelianrandomizationstudy AT jiangyuan associationbetweentype1diabetesmellitusandesophagealvaricesamendelianrandomizationstudy AT yanhuiwei associationbetweentype1diabetesmellitusandesophagealvaricesamendelianrandomizationstudy AT minli associationbetweentype1diabetesmellitusandesophagealvaricesamendelianrandomizationstudy |