Growth factor receptor plasticity drives therapeutic persistence of metastatic breast cancer

Abstract Metastatic breast cancer (MBC) remains a therapeutic challenge due to the persistence of minimal residual disease (MRD) and tumor recurrence. Herein we utilize a model of MBC that is sensitive to inhibition of fibroblast growth factor receptor (FGFR), resulting in robust regression of pulmo...

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Bibliographic Details
Main Authors: Mitchell Ayers, Marvis Monteiro, Aneesha Kulkarni, Julie W. Reeser, Emily Dykhuizen, Sameek Roychowdhury, Michael K. Wendt
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07591-3
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