Dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritis
This study examined how dietary apigenin supplementation influences growth performance, intestinal barrier integrity, and immune response in broilers affected by necrotic enteritis. A total of 144 one-day-old white-feathered broilers were divided into six groups. The NE model groups were inoculated...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-11-01
|
| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579125008740 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849228476344696832 |
|---|---|
| author | Yiming. Li Qiyuan. Zhao Qi. Zhang Nihar. Ali Xiaofang. Wei Wenwen. Yang Jia. Cao Ting. Xu Shiqi. Luo Hongbin. Si |
| author_facet | Yiming. Li Qiyuan. Zhao Qi. Zhang Nihar. Ali Xiaofang. Wei Wenwen. Yang Jia. Cao Ting. Xu Shiqi. Luo Hongbin. Si |
| author_sort | Yiming. Li |
| collection | DOAJ |
| description | This study examined how dietary apigenin supplementation influences growth performance, intestinal barrier integrity, and immune response in broilers affected by necrotic enteritis. A total of 144 one-day-old white-feathered broilers were divided into six groups. The NE model groups were inoculated with Eimeria maxima on day 14 and Clostridium perfringens (CP) on days 17-23. With the exception of the NE and NC groups, all other groups received dietary intervention with apigenin from day 24 to day 28. The results demonstrated that NE significantly reduced average daily gain (ADG) and feed conversion ratio (FCR), impaired antioxidant capacity, increased intestinal permeability, elevated anti-inflammatory cytokine (IL-10) and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), and suppressed intestinal barrier-related gene expression (P < 0.05). Dietary supplementation with 500 mg/kg apigenin effectively mitigated NE-induced damage by enhancing antioxidant activity, modulating immune responses, restoring intestinal morphology, and alleviating inflammatory reactions. |
| format | Article |
| id | doaj-art-e038864ec9524010b31a6194e1f06f02 |
| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-e038864ec9524010b31a6194e1f06f022025-08-23T04:47:21ZengElsevierPoultry Science0032-57912025-11-011041110563310.1016/j.psj.2025.105633Dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritisYiming. Li0Qiyuan. Zhao1Qi. Zhang2Nihar. Ali3Xiaofang. Wei4Wenwen. Yang5Jia. Cao6Ting. Xu7Shiqi. Luo8Hongbin. Si9College of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaCorresponding author.; College of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi University, Nanning, 530004, Guangxi, ChinaThis study examined how dietary apigenin supplementation influences growth performance, intestinal barrier integrity, and immune response in broilers affected by necrotic enteritis. A total of 144 one-day-old white-feathered broilers were divided into six groups. The NE model groups were inoculated with Eimeria maxima on day 14 and Clostridium perfringens (CP) on days 17-23. With the exception of the NE and NC groups, all other groups received dietary intervention with apigenin from day 24 to day 28. The results demonstrated that NE significantly reduced average daily gain (ADG) and feed conversion ratio (FCR), impaired antioxidant capacity, increased intestinal permeability, elevated anti-inflammatory cytokine (IL-10) and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), and suppressed intestinal barrier-related gene expression (P < 0.05). Dietary supplementation with 500 mg/kg apigenin effectively mitigated NE-induced damage by enhancing antioxidant activity, modulating immune responses, restoring intestinal morphology, and alleviating inflammatory reactions.http://www.sciencedirect.com/science/article/pii/S0032579125008740ApigeninBroilersNecrotic enteritisGrowth performanceIntestinal health |
| spellingShingle | Yiming. Li Qiyuan. Zhao Qi. Zhang Nihar. Ali Xiaofang. Wei Wenwen. Yang Jia. Cao Ting. Xu Shiqi. Luo Hongbin. Si Dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritis Poultry Science Apigenin Broilers Necrotic enteritis Growth performance Intestinal health |
| title | Dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritis |
| title_full | Dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritis |
| title_fullStr | Dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritis |
| title_full_unstemmed | Dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritis |
| title_short | Dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritis |
| title_sort | dietary supplementation with apigenin ameliorates intestinal injury in broilers suffering from necrotic enteritis |
| topic | Apigenin Broilers Necrotic enteritis Growth performance Intestinal health |
| url | http://www.sciencedirect.com/science/article/pii/S0032579125008740 |
| work_keys_str_mv | AT yimingli dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT qiyuanzhao dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT qizhang dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT niharali dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT xiaofangwei dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT wenwenyang dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT jiacao dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT tingxu dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT shiqiluo dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis AT hongbinsi dietarysupplementationwithapigeninamelioratesintestinalinjuryinbroilerssufferingfromnecroticenteritis |