Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, China
BackgroundIn the era of the COVID-19 pandemic, people living with HIV (PLWH) face more challenges. However, it is unclear if PLWH is more susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than HIV-negative individuals. This study aimed to explore the prevalenc...
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Frontiers Media S.A.
2022-04-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.833783/full |
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| author | Mengmeng Wu Mengmeng Wu Fangzhao Ming Songjie Wu Yanbin Liu Xiaoxia Zhang Wei Guo Wei Guo Gifty Marley Weiming Tang Weiming Tang Ke Liang Ke Liang Ke Liang Ke Liang |
| author_facet | Mengmeng Wu Mengmeng Wu Fangzhao Ming Songjie Wu Yanbin Liu Xiaoxia Zhang Wei Guo Wei Guo Gifty Marley Weiming Tang Weiming Tang Ke Liang Ke Liang Ke Liang Ke Liang |
| author_sort | Mengmeng Wu |
| collection | DOAJ |
| description | BackgroundIn the era of the COVID-19 pandemic, people living with HIV (PLWH) face more challenges. However, it is unclear if PLWH is more susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than HIV-negative individuals. This study aimed to explore the prevalence of the SARS-CoV-2 infection and the associated risk factors among PLWH.MethodsFrom 1 to 30 May 2020, we conducted a cross-sectional survey that enrolled 857 PLWH and 1,048 HIV-negative individuals from the Wuchang district in Wuhan, China. Our data analysis compared the rate of the SARS-CoV-2 infection among PLWH and HIV-negative participants, and the proportions of symptomatic patients and asymptomatic infectors between the two groups. We also assessed the risk factors associated with the SARS-CoV-2 infection among PLWH.ResultsOverall, 14/857 (1.6%) PLWH and 68/1,048 (6.5%) HIV-negative participants were infected with SARS-CoV-2. Among the SARS-CoV-2-infected PLWH participants, 6/14 (42.8%) were symptomatic patients, 4/14 (28.6%) were SARS-CoV-2 nucleic acid-positive asymptomatic infectors, and 4/14 (28.6%) were serology-positive asymptomatic infectors. Among the infected HIV-negative participants, 5/68 (7.4%) patients were symptomatic and 63/68 (92.6%) were serology-positive asymptomatic infectors. The rate of the SARS-CoV-2 infection was lower among the PLWH than in the HIV-negative group (1.96% vs. 5.74%, p = 0.001) and the rate of morbidity among the symptomatic patients was similar between the two groups (p = 0.107). However, there were more serology-positive asymptomatic infectors among the infected HIV-negative participants than among the infected PLWH (0.54% vs. 5.46%, p = 0.001). Furthermore, being 50 years or older (aOR = 4.50, 95% CI: 1.34–15.13, p = 0.015) and having opportunistic infections (aOR = 9.59, 95% CI: 1.54–59.92, p = 0.016) were associated with an increased risk of SARS-CoV-2 infection among PLWH.ConclusionsPLWH has more varied forms of the SARS-CoV-2 infection than the HIV-negative population and should, therefore, undertake routine screening to avoid late diagnosis. Also, older age (≥50 years) and having opportunistic infections increase the risks of SARS-CoV-2 infection among PLWH. |
| format | Article |
| id | doaj-art-e0377f48cb834706b2fc6c313e692778 |
| institution | OA Journals |
| issn | 2296-2565 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-e0377f48cb834706b2fc6c313e6927782025-08-20T01:54:31ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-04-011010.3389/fpubh.2022.833783833783Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, ChinaMengmeng Wu0Mengmeng Wu1Fangzhao Ming2Songjie Wu3Yanbin Liu4Xiaoxia Zhang5Wei Guo6Wei Guo7Gifty Marley8Weiming Tang9Weiming Tang10Ke Liang11Ke Liang12Ke Liang13Ke Liang14Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, ChinaWuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, ChinaWuchang District Center for Disease Control and Prevention, Wuhan, ChinaDepartment of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Pathology, School of Basic Medical Sciences, Wuhan University, Wuhan, ChinaSchool of Public Health of Nanjing Medical University, Nanjing, ChinaGuangdong Second Provincial General Hospital, Guangzhou, ChinaUniversity of North Carolina at Chapel Hill Project-China, Guangzhou, ChinaDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, ChinaWuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, ChinaDepartment of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China0Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment, Wuhan, ChinaBackgroundIn the era of the COVID-19 pandemic, people living with HIV (PLWH) face more challenges. However, it is unclear if PLWH is more susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than HIV-negative individuals. This study aimed to explore the prevalence of the SARS-CoV-2 infection and the associated risk factors among PLWH.MethodsFrom 1 to 30 May 2020, we conducted a cross-sectional survey that enrolled 857 PLWH and 1,048 HIV-negative individuals from the Wuchang district in Wuhan, China. Our data analysis compared the rate of the SARS-CoV-2 infection among PLWH and HIV-negative participants, and the proportions of symptomatic patients and asymptomatic infectors between the two groups. We also assessed the risk factors associated with the SARS-CoV-2 infection among PLWH.ResultsOverall, 14/857 (1.6%) PLWH and 68/1,048 (6.5%) HIV-negative participants were infected with SARS-CoV-2. Among the SARS-CoV-2-infected PLWH participants, 6/14 (42.8%) were symptomatic patients, 4/14 (28.6%) were SARS-CoV-2 nucleic acid-positive asymptomatic infectors, and 4/14 (28.6%) were serology-positive asymptomatic infectors. Among the infected HIV-negative participants, 5/68 (7.4%) patients were symptomatic and 63/68 (92.6%) were serology-positive asymptomatic infectors. The rate of the SARS-CoV-2 infection was lower among the PLWH than in the HIV-negative group (1.96% vs. 5.74%, p = 0.001) and the rate of morbidity among the symptomatic patients was similar between the two groups (p = 0.107). However, there were more serology-positive asymptomatic infectors among the infected HIV-negative participants than among the infected PLWH (0.54% vs. 5.46%, p = 0.001). Furthermore, being 50 years or older (aOR = 4.50, 95% CI: 1.34–15.13, p = 0.015) and having opportunistic infections (aOR = 9.59, 95% CI: 1.54–59.92, p = 0.016) were associated with an increased risk of SARS-CoV-2 infection among PLWH.ConclusionsPLWH has more varied forms of the SARS-CoV-2 infection than the HIV-negative population and should, therefore, undertake routine screening to avoid late diagnosis. Also, older age (≥50 years) and having opportunistic infections increase the risks of SARS-CoV-2 infection among PLWH.https://www.frontiersin.org/articles/10.3389/fpubh.2022.833783/fullSARS-CoV-2people living with human immunodeficiency virus (PLWH)IgGIgMasymptomatic infectorssymptomatic patient |
| spellingShingle | Mengmeng Wu Mengmeng Wu Fangzhao Ming Songjie Wu Yanbin Liu Xiaoxia Zhang Wei Guo Wei Guo Gifty Marley Weiming Tang Weiming Tang Ke Liang Ke Liang Ke Liang Ke Liang Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, China Frontiers in Public Health SARS-CoV-2 people living with human immunodeficiency virus (PLWH) IgG IgM asymptomatic infectors symptomatic patient |
| title | Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, China |
| title_full | Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, China |
| title_fullStr | Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, China |
| title_full_unstemmed | Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, China |
| title_short | Risk of SARS-CoV-2 Infection Among People Living With HIV in Wuhan, China |
| title_sort | risk of sars cov 2 infection among people living with hiv in wuhan china |
| topic | SARS-CoV-2 people living with human immunodeficiency virus (PLWH) IgG IgM asymptomatic infectors symptomatic patient |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.833783/full |
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