Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall
Prolymphocytic transformation is a concept usually applied in the context of chronic lymphocytic leukemia/small lymphocytic lymphoma to describe the presence of a high percentage of prolymphocytes in peripheral blood (usually more than 55%). Prolymphocytic transformation has also been reported in ma...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/5761953 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552600219680768 |
|---|---|
| author | Khaled Algashaamy Yaohong Tan Nicolas Mackrides Alvaro Alencar Jing-Hong Peng Joseph Rosenblatt Juan P Alderuccio Izidore S. Lossos Francisco Vega Jennifer Chapman |
| author_facet | Khaled Algashaamy Yaohong Tan Nicolas Mackrides Alvaro Alencar Jing-Hong Peng Joseph Rosenblatt Juan P Alderuccio Izidore S. Lossos Francisco Vega Jennifer Chapman |
| author_sort | Khaled Algashaamy |
| collection | DOAJ |
| description | Prolymphocytic transformation is a concept usually applied in the context of chronic lymphocytic leukemia/small lymphocytic lymphoma to describe the presence of a high percentage of prolymphocytes in peripheral blood (usually more than 55%). Prolymphocytic transformation has also been reported in mantle cell lymphoma (MCL) but only rarely in splenic marginal zone lymphoma (SMZL). We present two splenic B-cell lymphomas presenting in the leukemic phase and with increased prolymphocytes, both classified as SMZL with prolymphocytic transformation. One case clinically simulated B-prolymphocytic leukemia (B-PLL). Both lymphomas were very unusual because the tumor cells diffusely and strongly expressed cyclin D1 despite lacking the t(11; 14)(q13; q32) as detected by several approaches including next-generation sequencing, fluorescence in situ hybridization using CCND1 break apart probe and fusion probes for t(11; 14)(q13; q32), and conventional karyotyping. These cases therefore simulated prolymphocytic variants of MCL. The incidence of this phenomenon is unknown, and awareness of this potential alternate protein expression pattern is important in order to avoid diagnostic errors. |
| format | Article |
| id | doaj-art-e0347edd38c74935894e8a425f5e8bd3 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-e0347edd38c74935894e8a425f5e8bd32025-02-03T05:58:17ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/57619535761953Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic PitfallKhaled Algashaamy0Yaohong Tan1Nicolas Mackrides2Alvaro Alencar3Jing-Hong Peng4Joseph Rosenblatt5Juan P Alderuccio6Izidore S. Lossos7Francisco Vega8Jennifer Chapman9Department of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Medicine, Division of Hematology-Oncology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Medicine, Division of Hematology-Oncology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Medicine, Division of Hematology-Oncology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Medicine, Division of Hematology-Oncology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USADepartment of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USAProlymphocytic transformation is a concept usually applied in the context of chronic lymphocytic leukemia/small lymphocytic lymphoma to describe the presence of a high percentage of prolymphocytes in peripheral blood (usually more than 55%). Prolymphocytic transformation has also been reported in mantle cell lymphoma (MCL) but only rarely in splenic marginal zone lymphoma (SMZL). We present two splenic B-cell lymphomas presenting in the leukemic phase and with increased prolymphocytes, both classified as SMZL with prolymphocytic transformation. One case clinically simulated B-prolymphocytic leukemia (B-PLL). Both lymphomas were very unusual because the tumor cells diffusely and strongly expressed cyclin D1 despite lacking the t(11; 14)(q13; q32) as detected by several approaches including next-generation sequencing, fluorescence in situ hybridization using CCND1 break apart probe and fusion probes for t(11; 14)(q13; q32), and conventional karyotyping. These cases therefore simulated prolymphocytic variants of MCL. The incidence of this phenomenon is unknown, and awareness of this potential alternate protein expression pattern is important in order to avoid diagnostic errors.http://dx.doi.org/10.1155/2018/5761953 |
| spellingShingle | Khaled Algashaamy Yaohong Tan Nicolas Mackrides Alvaro Alencar Jing-Hong Peng Joseph Rosenblatt Juan P Alderuccio Izidore S. Lossos Francisco Vega Jennifer Chapman Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall Case Reports in Hematology |
| title | Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall |
| title_full | Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall |
| title_fullStr | Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall |
| title_full_unstemmed | Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall |
| title_short | Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall |
| title_sort | splenic b cell lymphomas with diffuse cyclin d1 protein expression and increased prolymphocytic cells a previously unrecognized diagnostic pitfall |
| url | http://dx.doi.org/10.1155/2018/5761953 |
| work_keys_str_mv | AT khaledalgashaamy splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT yaohongtan splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT nicolasmackrides splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT alvaroalencar splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT jinghongpeng splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT josephrosenblatt splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT juanpalderuccio splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT izidoreslossos splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT franciscovega splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall AT jenniferchapman splenicbcelllymphomaswithdiffusecyclind1proteinexpressionandincreasedprolymphocyticcellsapreviouslyunrecognizeddiagnosticpitfall |