ADP-ribose hydrolases: biological functions and potential therapeutic targets
ADP-ribosylation (ADPRylation), which encompasses poly(ADP-ribosyl)ation and mono(ADP-ribosyl)ation, is an important post-translational modification catalysed by the poly(ADP-ribose) polymerase (PARP) enzyme superfamily. The process involves writers (PARPs) and erasers (ADP-ribose hydrolases), which...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2024-01-01
|
| Series: | Expert Reviews in Molecular Medicine |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399424000176/type/journal_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849233077475213312 |
|---|---|
| author | Jingpeng Wang Zhao-Qi Wang Wen Zong |
| author_facet | Jingpeng Wang Zhao-Qi Wang Wen Zong |
| author_sort | Jingpeng Wang |
| collection | DOAJ |
| description | ADP-ribosylation (ADPRylation), which encompasses poly(ADP-ribosyl)ation and mono(ADP-ribosyl)ation, is an important post-translational modification catalysed by the poly(ADP-ribose) polymerase (PARP) enzyme superfamily. The process involves writers (PARPs) and erasers (ADP-ribose hydrolases), which work together to precisely regulate diverse cellular and molecular responses. Although the PARP-mediated synthesis of ADP-ribose (ADPr) has been well studied, ADPr degradation by degrading enzymes deserves further investigation. Nonetheless, recent studies have provided important new insights into the biology and functions of ADPr hydrolases. Notably, research has illuminated the significance of the poly(ADP-ribose) degradation pathway and its activation by the coordinated actions of poly(ADP-ribose) glycohydrolase and other ADPr hydrolases, which have been identified as key components of ADPRylation signalling networks. The degradation pathway has been proposed to play crucial roles in key cellular processes, such as DNA damage repair, chromatin dynamics, transcriptional regulation and cell death. A deep understanding of these ADPr erasing enzymes provides insights into the biological roles of ADPRylation in human health and disease aetiology and paves the road for the development of novel therapeutic strategies. This review article provides a summary of current knowledge about the biochemical and molecular functions of ADPr erasers and their physiological implications in human pathology. |
| format | Article |
| id | doaj-art-e030e8b254fc46659480c2de41e9c22c |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-e030e8b254fc46659480c2de41e9c22c2025-08-20T12:57:31ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942024-01-012610.1017/erm.2024.17ADP-ribose hydrolases: biological functions and potential therapeutic targetsJingpeng Wang0Zhao-Qi Wang1Wen Zong2https://orcid.org/0000-0001-7800-128XState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P. R. ChinaState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P. R. China Faculty of Biological Sciences, Friedrich-Schiller University of Jena, Jena 07743, GermanyState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P. R. ChinaADP-ribosylation (ADPRylation), which encompasses poly(ADP-ribosyl)ation and mono(ADP-ribosyl)ation, is an important post-translational modification catalysed by the poly(ADP-ribose) polymerase (PARP) enzyme superfamily. The process involves writers (PARPs) and erasers (ADP-ribose hydrolases), which work together to precisely regulate diverse cellular and molecular responses. Although the PARP-mediated synthesis of ADP-ribose (ADPr) has been well studied, ADPr degradation by degrading enzymes deserves further investigation. Nonetheless, recent studies have provided important new insights into the biology and functions of ADPr hydrolases. Notably, research has illuminated the significance of the poly(ADP-ribose) degradation pathway and its activation by the coordinated actions of poly(ADP-ribose) glycohydrolase and other ADPr hydrolases, which have been identified as key components of ADPRylation signalling networks. The degradation pathway has been proposed to play crucial roles in key cellular processes, such as DNA damage repair, chromatin dynamics, transcriptional regulation and cell death. A deep understanding of these ADPr erasing enzymes provides insights into the biological roles of ADPRylation in human health and disease aetiology and paves the road for the development of novel therapeutic strategies. This review article provides a summary of current knowledge about the biochemical and molecular functions of ADPr erasers and their physiological implications in human pathology.https://www.cambridge.org/core/product/identifier/S1462399424000176/type/journal_articleADP-ribose hydrolasesADP-ribosylationPARPs |
| spellingShingle | Jingpeng Wang Zhao-Qi Wang Wen Zong ADP-ribose hydrolases: biological functions and potential therapeutic targets Expert Reviews in Molecular Medicine ADP-ribose hydrolases ADP-ribosylation PARPs |
| title | ADP-ribose hydrolases: biological functions and potential therapeutic targets |
| title_full | ADP-ribose hydrolases: biological functions and potential therapeutic targets |
| title_fullStr | ADP-ribose hydrolases: biological functions and potential therapeutic targets |
| title_full_unstemmed | ADP-ribose hydrolases: biological functions and potential therapeutic targets |
| title_short | ADP-ribose hydrolases: biological functions and potential therapeutic targets |
| title_sort | adp ribose hydrolases biological functions and potential therapeutic targets |
| topic | ADP-ribose hydrolases ADP-ribosylation PARPs |
| url | https://www.cambridge.org/core/product/identifier/S1462399424000176/type/journal_article |
| work_keys_str_mv | AT jingpengwang adpribosehydrolasesbiologicalfunctionsandpotentialtherapeutictargets AT zhaoqiwang adpribosehydrolasesbiologicalfunctionsandpotentialtherapeutictargets AT wenzong adpribosehydrolasesbiologicalfunctionsandpotentialtherapeutictargets |