Alcohol consumption may not be a risk factor for sarcopenia in the older adults
The relationship between drinking and sarcopenia remains controversial. The aim of the present study was to investigate the association of alcohol drinking with sarcopenia in the older adults. A prospective study with 5244 Chinese community-dwelling older adults aged ≥65 years was performed. Sarcope...
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Frontiers Media S.A.
2025-05-01
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| Series: | Experimental Biology and Medicine |
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| Online Access: | https://www.ebm-journal.org/articles/10.3389/ebm.2025.10520/full |
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| author | En-Hui Mao Yun-Ling Bu Qiao-Ling Liu Jin-Shui Xu Xiang Lu Xi-Lan Yang Wei Gao Zheng-Kai Shen |
| author_facet | En-Hui Mao Yun-Ling Bu Qiao-Ling Liu Jin-Shui Xu Xiang Lu Xi-Lan Yang Wei Gao Zheng-Kai Shen |
| author_sort | En-Hui Mao |
| collection | DOAJ |
| description | The relationship between drinking and sarcopenia remains controversial. The aim of the present study was to investigate the association of alcohol drinking with sarcopenia in the older adults. A prospective study with 5244 Chinese community-dwelling older adults aged ≥65 years was performed. Sarcopenia was assessed by appendicular skeletal muscle mass index, grip strength, and gait speed. A quantitative questionnaire was used to obtain the information of alcohol drinking. After 4-year follow-up, our study showed that drinkers had lower incidence of sarcopenia than those non-drinkers (19.4% vs. 30.4%, P < 0.001 in males and 9.5% vs. 20.4%, P = 0.004 in females, respectively). Moreover, male drinkers had higher levels of muscle mass [median (IQR): 7.3 (6.7–7.9) kg/m2 vs. 7.1 (6.5–7.7) kg/m2, P < 0.001] grip strength [median (IQR): 31.1 (26.5–35.0) kg vs. 29.6 (24.8–38.8) kg, P < 0.001], and gait speed [median (IQR): 1.08 (0.98–1.17) m/s vs. 1.05 (0.94–1.15) m/s, P < 0.001] than those non-drinkers, while female drinkers had higher gait speed [median (IQR): 1.02 (0.94–1.11) m/s vs. 0.99 (0.89–1.09) m/s, P = 0.031] than those non-drinkers. Multivariate logistic regression showed that in older adults younger than 85 years, both interim drinking (RR = 0.60; 95%CI = 0.39–0.93; P = 0.021 for males; RR = 0.36; 95%CI = 0.13–0.90; P = 0.035 for females) and daily drinking (RR = 0.78; 95%CI = 0.61–0.99; P = 0.045 for males; RR = 0.34; 95%CI = 0.12–0.96; P = 0.041 for females) were correlated with decreased risk of sarcopenia even after adjustment for confounding factors. However, our dose-response analysis did not show any significant relationship between daily alcohol intake and the risk of sarcopenia as well as the components of sarcopenia. In conclusion, our results indicated that alcohol drinking may not be a risk factor for sarcopenia in the older adults. Further research will help to understand the underlying mechanism of the observed causal relationship. |
| format | Article |
| id | doaj-art-e03087a4de8d40f3b59bec91aac2686f |
| institution | DOAJ |
| issn | 1535-3699 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-e03087a4de8d40f3b59bec91aac2686f2025-08-20T03:22:19ZengFrontiers Media S.A.Experimental Biology and Medicine1535-36992025-05-0125010.3389/ebm.2025.1052010520Alcohol consumption may not be a risk factor for sarcopenia in the older adultsEn-Hui Mao0Yun-Ling Bu1Qiao-Ling Liu2Jin-Shui Xu3Xiang Lu4Xi-Lan Yang5Wei Gao6Zheng-Kai Shen7Department of Endocrinology, Danyang Hospital of Traditional Medicine, Danyang, ChinaDepartment of General Practice, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, The First People’s Hospital of Lianyungang, Lianyungang, ChinaJiangsu Province Center for Disease Control and Prevention, Nanjing, ChinaDepartment of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of General Practice, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaJiangsu Province Center for Disease Control and Prevention, Nanjing, ChinaThe relationship between drinking and sarcopenia remains controversial. The aim of the present study was to investigate the association of alcohol drinking with sarcopenia in the older adults. A prospective study with 5244 Chinese community-dwelling older adults aged ≥65 years was performed. Sarcopenia was assessed by appendicular skeletal muscle mass index, grip strength, and gait speed. A quantitative questionnaire was used to obtain the information of alcohol drinking. After 4-year follow-up, our study showed that drinkers had lower incidence of sarcopenia than those non-drinkers (19.4% vs. 30.4%, P < 0.001 in males and 9.5% vs. 20.4%, P = 0.004 in females, respectively). Moreover, male drinkers had higher levels of muscle mass [median (IQR): 7.3 (6.7–7.9) kg/m2 vs. 7.1 (6.5–7.7) kg/m2, P < 0.001] grip strength [median (IQR): 31.1 (26.5–35.0) kg vs. 29.6 (24.8–38.8) kg, P < 0.001], and gait speed [median (IQR): 1.08 (0.98–1.17) m/s vs. 1.05 (0.94–1.15) m/s, P < 0.001] than those non-drinkers, while female drinkers had higher gait speed [median (IQR): 1.02 (0.94–1.11) m/s vs. 0.99 (0.89–1.09) m/s, P = 0.031] than those non-drinkers. Multivariate logistic regression showed that in older adults younger than 85 years, both interim drinking (RR = 0.60; 95%CI = 0.39–0.93; P = 0.021 for males; RR = 0.36; 95%CI = 0.13–0.90; P = 0.035 for females) and daily drinking (RR = 0.78; 95%CI = 0.61–0.99; P = 0.045 for males; RR = 0.34; 95%CI = 0.12–0.96; P = 0.041 for females) were correlated with decreased risk of sarcopenia even after adjustment for confounding factors. However, our dose-response analysis did not show any significant relationship between daily alcohol intake and the risk of sarcopenia as well as the components of sarcopenia. In conclusion, our results indicated that alcohol drinking may not be a risk factor for sarcopenia in the older adults. Further research will help to understand the underlying mechanism of the observed causal relationship.https://www.ebm-journal.org/articles/10.3389/ebm.2025.10520/fullalcoholsarcopeniaolder adultscommunity-dwellingodds ratio |
| spellingShingle | En-Hui Mao Yun-Ling Bu Qiao-Ling Liu Jin-Shui Xu Xiang Lu Xi-Lan Yang Wei Gao Zheng-Kai Shen Alcohol consumption may not be a risk factor for sarcopenia in the older adults Experimental Biology and Medicine alcohol sarcopenia older adults community-dwelling odds ratio |
| title | Alcohol consumption may not be a risk factor for sarcopenia in the older adults |
| title_full | Alcohol consumption may not be a risk factor for sarcopenia in the older adults |
| title_fullStr | Alcohol consumption may not be a risk factor for sarcopenia in the older adults |
| title_full_unstemmed | Alcohol consumption may not be a risk factor for sarcopenia in the older adults |
| title_short | Alcohol consumption may not be a risk factor for sarcopenia in the older adults |
| title_sort | alcohol consumption may not be a risk factor for sarcopenia in the older adults |
| topic | alcohol sarcopenia older adults community-dwelling odds ratio |
| url | https://www.ebm-journal.org/articles/10.3389/ebm.2025.10520/full |
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