Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells
Dendritic cells (DC) play an important role in the pathogenesis of systemic lupus erythematosus (SLE), an autoimmune disease with multiple tissue manifestations. In this review, we summarize recent studies on the roles of conventional DC and plasmacytoid DC in the development of both murine lupus an...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6269157 |
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| author | Xiaofeng Liao Alec M. Reihl Xin M. Luo |
| author_facet | Xiaofeng Liao Alec M. Reihl Xin M. Luo |
| author_sort | Xiaofeng Liao |
| collection | DOAJ |
| description | Dendritic cells (DC) play an important role in the pathogenesis of systemic lupus erythematosus (SLE), an autoimmune disease with multiple tissue manifestations. In this review, we summarize recent studies on the roles of conventional DC and plasmacytoid DC in the development of both murine lupus and human SLE. In the past decade, studies using selective DC depletions have demonstrated critical roles of DC in lupus progression. Comprehensive in vitro and in vivo studies suggest activation of DC by self-antigens in lupus pathogenesis, followed by breakdown of immune tolerance to self. Potential treatment strategies targeting DC have been developed. However, many questions remain regarding the mechanisms by which DC modulate lupus pathogenesis that require further investigations. |
| format | Article |
| id | doaj-art-e02f002f33c14abbbb755edc24b4a56f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e02f002f33c14abbbb755edc24b4a56f2025-08-20T03:26:09ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/62691576269157Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic CellsXiaofeng Liao0Alec M. Reihl1Xin M. Luo2Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USADepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USADepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USADendritic cells (DC) play an important role in the pathogenesis of systemic lupus erythematosus (SLE), an autoimmune disease with multiple tissue manifestations. In this review, we summarize recent studies on the roles of conventional DC and plasmacytoid DC in the development of both murine lupus and human SLE. In the past decade, studies using selective DC depletions have demonstrated critical roles of DC in lupus progression. Comprehensive in vitro and in vivo studies suggest activation of DC by self-antigens in lupus pathogenesis, followed by breakdown of immune tolerance to self. Potential treatment strategies targeting DC have been developed. However, many questions remain regarding the mechanisms by which DC modulate lupus pathogenesis that require further investigations.http://dx.doi.org/10.1155/2016/6269157 |
| spellingShingle | Xiaofeng Liao Alec M. Reihl Xin M. Luo Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells Journal of Immunology Research |
| title | Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells |
| title_full | Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells |
| title_fullStr | Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells |
| title_full_unstemmed | Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells |
| title_short | Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells |
| title_sort | breakdown of immune tolerance in systemic lupus erythematosus by dendritic cells |
| url | http://dx.doi.org/10.1155/2016/6269157 |
| work_keys_str_mv | AT xiaofengliao breakdownofimmunetoleranceinsystemiclupuserythematosusbydendriticcells AT alecmreihl breakdownofimmunetoleranceinsystemiclupuserythematosusbydendriticcells AT xinmluo breakdownofimmunetoleranceinsystemiclupuserythematosusbydendriticcells |