Burkholderia cepacia complex bacteremia outbreaks among non-cystic fibrosis patients in the pediatric unit of a university hospital
Background. Burkholderia cepacia complex (Bcc) comprises multi-drug resistant, Gram-negative, motile, and aerobic bacteria. Bcc causes severe nosocomial infections particularly in patients with intravascular catheters and in those with cystic fibrosis. We studied a Bcc outbreak in non-cystic...
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Hacettepe University Institute of Child Health
2021-04-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/291 |
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| author | Sinan Tüfekci Birol Şafak Burçin Nalbantoğlu Nedim Samancı Nuri Kiraz |
| author_facet | Sinan Tüfekci Birol Şafak Burçin Nalbantoğlu Nedim Samancı Nuri Kiraz |
| author_sort | Sinan Tüfekci |
| collection | DOAJ |
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Background. Burkholderia cepacia complex (Bcc) comprises multi-drug resistant, Gram-negative, motile, and aerobic bacteria. Bcc causes severe nosocomial infections particularly in patients with intravascular catheters and in those with cystic fibrosis. We studied a Bcc outbreak in non-cystic fibrosis patients.
Methods. We analyzed data from six patients hospitalized at our center. Blood cultures identified as infectious were incubated onto 5% blood sheep agar, chocolate agar, and eosin methylene blue (EMB) agar. We examined possible sites that could be sources of infection at the clinic. We confirmed isolations with pulsed-field gel electrophoresis (PFGE) tests.
Results. The first patient was hospitalized due to left renal agenesis, urinary tract infection, and renal failure. Bcc was isolated in blood cultures obtained due to high fever on the third day of hospitalization. We stopped new patient hospitalizations after detecting Bcc in blood cultures of other five patients. We did not detect further positive specimens obtained from other clinic and the patient rooms. PFGE patterns were similar in all clinical isolates of Bcc indicating that the outbreak had originated from the source.
Conclusions. Bcc infection should be considered in cases of nosocomial outbreaks of multi-drug resistant organisms that require hospitalization at intensive care units. Control measures should be taken for prevention of nosocomial infections and required investigations should be done to detect the source of infection.
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| format | Article |
| id | doaj-art-e02eabc1fc4a46f2be8abd6b0ed32526 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-e02eabc1fc4a46f2be8abd6b0ed325262025-08-20T03:00:51ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212021-04-0163210.24953/turkjped.2021.02.005Burkholderia cepacia complex bacteremia outbreaks among non-cystic fibrosis patients in the pediatric unit of a university hospitalSinan Tüfekci0Birol Şafak1Burçin Nalbantoğlu2Nedim Samancı3Nuri Kiraz4Departments of Pediatrics, Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey.Departments of Microbiology, Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey.Departments of Pediatrics, Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey.Departments of Pediatrics, Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey.Departments of Microbiology, Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey. Background. Burkholderia cepacia complex (Bcc) comprises multi-drug resistant, Gram-negative, motile, and aerobic bacteria. Bcc causes severe nosocomial infections particularly in patients with intravascular catheters and in those with cystic fibrosis. We studied a Bcc outbreak in non-cystic fibrosis patients. Methods. We analyzed data from six patients hospitalized at our center. Blood cultures identified as infectious were incubated onto 5% blood sheep agar, chocolate agar, and eosin methylene blue (EMB) agar. We examined possible sites that could be sources of infection at the clinic. We confirmed isolations with pulsed-field gel electrophoresis (PFGE) tests. Results. The first patient was hospitalized due to left renal agenesis, urinary tract infection, and renal failure. Bcc was isolated in blood cultures obtained due to high fever on the third day of hospitalization. We stopped new patient hospitalizations after detecting Bcc in blood cultures of other five patients. We did not detect further positive specimens obtained from other clinic and the patient rooms. PFGE patterns were similar in all clinical isolates of Bcc indicating that the outbreak had originated from the source. Conclusions. Bcc infection should be considered in cases of nosocomial outbreaks of multi-drug resistant organisms that require hospitalization at intensive care units. Control measures should be taken for prevention of nosocomial infections and required investigations should be done to detect the source of infection. https://turkjpediatr.org/article/view/291Burkholderia cepacia complexchildinfection controlnon-cystic fibrosisoutbreak |
| spellingShingle | Sinan Tüfekci Birol Şafak Burçin Nalbantoğlu Nedim Samancı Nuri Kiraz Burkholderia cepacia complex bacteremia outbreaks among non-cystic fibrosis patients in the pediatric unit of a university hospital The Turkish Journal of Pediatrics Burkholderia cepacia complex child infection control non-cystic fibrosis outbreak |
| title | Burkholderia cepacia complex bacteremia outbreaks among non-cystic fibrosis patients in the pediatric unit of a university hospital |
| title_full | Burkholderia cepacia complex bacteremia outbreaks among non-cystic fibrosis patients in the pediatric unit of a university hospital |
| title_fullStr | Burkholderia cepacia complex bacteremia outbreaks among non-cystic fibrosis patients in the pediatric unit of a university hospital |
| title_full_unstemmed | Burkholderia cepacia complex bacteremia outbreaks among non-cystic fibrosis patients in the pediatric unit of a university hospital |
| title_short | Burkholderia cepacia complex bacteremia outbreaks among non-cystic fibrosis patients in the pediatric unit of a university hospital |
| title_sort | burkholderia cepacia complex bacteremia outbreaks among non cystic fibrosis patients in the pediatric unit of a university hospital |
| topic | Burkholderia cepacia complex child infection control non-cystic fibrosis outbreak |
| url | https://turkjpediatr.org/article/view/291 |
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