Zic3 enables bimodal regulation of tyrosine hydroxylase expression in olfactory bulb and midbrain-derived neurons

Zic3 enables bimodal regulation of tyrosine hydroxylase expression in olfactory bulb and midbrain-derived neurons

Abstract Tyrosine hydroxylase (TH) is the rate-limiting enzyme involved in the biosynthesis of catecholamines such as dopamine, norepinephrine, and epinephrine expressed in various regions of the brain, including the olfactory bulb (OB) and midbrain (MB). Previous studies demonstrated Zinc Finger tr...

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Main Authors: Smitha Bhaskar, Jeevan Gowda, Akshay Hegde, Surya Chandra Rao Thumu, Shreetama Banerjee, Helen M Bellchambers, Narendrakumar Ramanan, Paloma Merchan Sala, Kenneth Campbell, Stephanie Ware, Jyothi Prasanna, Anujith Kumar
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02448-2
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