Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han population
Abstract To evaluate the correlation between plasma fibrinogen levels and acute myocardial infarction (AMI) in the Chinese Han population. A total of 1522 patients with incident AMI and 6125 controls were recruited between January 1, 2010, and December 31, 2013. The relationship between fibrinogen l...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-08215-8 |
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| author | Jian-Ping Xu Yang He Xu Li Ting-Bo Jiang Heng Wang Li-Hong Zhang Dong-Ping Cai Xiao-Dong Qian Yong-Ming He |
| author_facet | Jian-Ping Xu Yang He Xu Li Ting-Bo Jiang Heng Wang Li-Hong Zhang Dong-Ping Cai Xiao-Dong Qian Yong-Ming He |
| author_sort | Jian-Ping Xu |
| collection | DOAJ |
| description | Abstract To evaluate the correlation between plasma fibrinogen levels and acute myocardial infarction (AMI) in the Chinese Han population. A total of 1522 patients with incident AMI and 6125 controls were recruited between January 1, 2010, and December 31, 2013. The relationship between fibrinogen levels and incident AMI was evaluated using multivariable-adjusted logistic regression, and the possible interaction effects between fibrinogen and other risk factors on incident AMI were investigated. When modeled as a continuous variable, a 1 g/L increase in fibrinogen level was associated with a 91% increase in the risk of AMI [odds ratio (OR):1.91; 95% confidence interval (CI):1.63–2.23 in women, 1.86:1.70–2.03 in men, and 1.85:1.72–2.00 in total]. Compared to 1st quartile of fibrinogen levels, the adjusted ORs for first incident AMI was 3.25 (2.67–3.96) for the fourth quartile, 1.61 (1.30–1.99) for the third one, 1.18 (0.96–1.46) for the second one (P < 0.001). High fibrinogen levels are associated with an increased risk of incident AMI in the Chinese Han population, and fibrinogen could be an important biomarker for AMI risk assessment. |
| format | Article |
| id | doaj-art-e02d8d50c3bf4fb4ad0724602d28ac0a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-e02d8d50c3bf4fb4ad0724602d28ac0a2025-08-20T03:38:12ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-08215-8Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han populationJian-Ping Xu0Yang He1Xu Li2Ting-Bo Jiang3Heng Wang4Li-Hong Zhang5Dong-Ping Cai6Xiao-Dong Qian7Yong-Ming He8Division of Cardiology, The First Affiliated Hospital of Soochow UniversityEmergency Department, The First Affiliated Hospital of Soochow UniversityDivision of Cardiology, The First Affiliated Hospital of Soochow UniversityDivision of Cardiology, The First Affiliated Hospital of Soochow UniversityDivision of Cardiology, The First Affiliated Hospital of Soochow UniversityDepartment of Neurological Intervention and Neurological Intensive Care Unit, The Central Hospital of Dalian University of TechnologyHealthcare Center for Shishan Street Community of Suzhou New DistrictDivision of Cardiology, The First Affiliated Hospital of Soochow UniversityDivision of Cardiology, The First Affiliated Hospital of Soochow UniversityAbstract To evaluate the correlation between plasma fibrinogen levels and acute myocardial infarction (AMI) in the Chinese Han population. A total of 1522 patients with incident AMI and 6125 controls were recruited between January 1, 2010, and December 31, 2013. The relationship between fibrinogen levels and incident AMI was evaluated using multivariable-adjusted logistic regression, and the possible interaction effects between fibrinogen and other risk factors on incident AMI were investigated. When modeled as a continuous variable, a 1 g/L increase in fibrinogen level was associated with a 91% increase in the risk of AMI [odds ratio (OR):1.91; 95% confidence interval (CI):1.63–2.23 in women, 1.86:1.70–2.03 in men, and 1.85:1.72–2.00 in total]. Compared to 1st quartile of fibrinogen levels, the adjusted ORs for first incident AMI was 3.25 (2.67–3.96) for the fourth quartile, 1.61 (1.30–1.99) for the third one, 1.18 (0.96–1.46) for the second one (P < 0.001). High fibrinogen levels are associated with an increased risk of incident AMI in the Chinese Han population, and fibrinogen could be an important biomarker for AMI risk assessment.https://doi.org/10.1038/s41598-025-08215-8FibrinogenAcute myocardial infarctionChinese Han populationOdds ratioCross-sectional study |
| spellingShingle | Jian-Ping Xu Yang He Xu Li Ting-Bo Jiang Heng Wang Li-Hong Zhang Dong-Ping Cai Xiao-Dong Qian Yong-Ming He Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han population Scientific Reports Fibrinogen Acute myocardial infarction Chinese Han population Odds ratio Cross-sectional study |
| title | Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han population |
| title_full | Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han population |
| title_fullStr | Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han population |
| title_full_unstemmed | Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han population |
| title_short | Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han population |
| title_sort | correlation of fibrinogen levels with acute myocardial infarction risk in the chinese han population |
| topic | Fibrinogen Acute myocardial infarction Chinese Han population Odds ratio Cross-sectional study |
| url | https://doi.org/10.1038/s41598-025-08215-8 |
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