The role of stem cells in the treatment of retinitis pigmentosa: Contemporary insights and future perspectives
Retinitis pigmentosa (RP) is a hereditary degenerative disorder distinguished by the gradual deterioration of retinal pigment epithelium (RPE) cells and photoreceptors. This condition typically presents with gradual night blindness, difficulties in color perception, central vision impairment, and ul...
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/25/bioconf_icbb2025_01002.pdf |
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| author | Wang Shiqi |
| author_facet | Wang Shiqi |
| author_sort | Wang Shiqi |
| collection | DOAJ |
| description | Retinitis pigmentosa (RP) is a hereditary degenerative disorder distinguished by the gradual deterioration of retinal pigment epithelium (RPE) cells and photoreceptors. This condition typically presents with gradual night blindness, difficulties in color perception, central vision impairment, and ultimately leads to blindness, predominantly affecting younger individuals. The irreversible loss of retinal cells poses significant challenges in the treatment of RP. Due to their distinctive potential to differentiate into various retinal cell types, stem cells have emerged as a promising therapeutic strategy for RP. Among the categories of stem cells under investigation, embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) are particularly prominent. In particular, bone marrow-derived MSCs (BM- MSCs) have shown both safety and efficacy in enhancing visual sharpness and retinal thickness in affected individuals. Moreover, recent studies have highlighted the differentiation potential of Müller glial cells into photoreceptor cells, broadening the scope for treatment. The incorporation of advanced bioengineering techniques-such as 3D bioprinting and gene editing-further enhances the prospects for innovative therapies. Despite significant progress in animal experiments and clinical trials, challenges remain, including uncertainties in cellular differentiation and complications arising from multifaceted retinal pathologies. This review aims to synthesize current insights into stem cell therapy for RP, emphasizing both achievements and ongoing challenges in the pursuit of effective treatments. |
| format | Article |
| id | doaj-art-e02d45b5a8c84e5f9a4a482a01dbed51 |
| institution | OA Journals |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-e02d45b5a8c84e5f9a4a482a01dbed512025-08-20T02:26:01ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011740100210.1051/bioconf/202517401002bioconf_icbb2025_01002The role of stem cells in the treatment of retinitis pigmentosa: Contemporary insights and future perspectivesWang Shiqi0School of Ophthaimology & Optometry (School of Biomedical Engineering), Wenzhou Medical UniversityRetinitis pigmentosa (RP) is a hereditary degenerative disorder distinguished by the gradual deterioration of retinal pigment epithelium (RPE) cells and photoreceptors. This condition typically presents with gradual night blindness, difficulties in color perception, central vision impairment, and ultimately leads to blindness, predominantly affecting younger individuals. The irreversible loss of retinal cells poses significant challenges in the treatment of RP. Due to their distinctive potential to differentiate into various retinal cell types, stem cells have emerged as a promising therapeutic strategy for RP. Among the categories of stem cells under investigation, embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) are particularly prominent. In particular, bone marrow-derived MSCs (BM- MSCs) have shown both safety and efficacy in enhancing visual sharpness and retinal thickness in affected individuals. Moreover, recent studies have highlighted the differentiation potential of Müller glial cells into photoreceptor cells, broadening the scope for treatment. The incorporation of advanced bioengineering techniques-such as 3D bioprinting and gene editing-further enhances the prospects for innovative therapies. Despite significant progress in animal experiments and clinical trials, challenges remain, including uncertainties in cellular differentiation and complications arising from multifaceted retinal pathologies. This review aims to synthesize current insights into stem cell therapy for RP, emphasizing both achievements and ongoing challenges in the pursuit of effective treatments.https://www.bio-conferences.org/articles/bioconf/pdf/2025/25/bioconf_icbb2025_01002.pdf |
| spellingShingle | Wang Shiqi The role of stem cells in the treatment of retinitis pigmentosa: Contemporary insights and future perspectives BIO Web of Conferences |
| title | The role of stem cells in the treatment of retinitis pigmentosa: Contemporary insights and future perspectives |
| title_full | The role of stem cells in the treatment of retinitis pigmentosa: Contemporary insights and future perspectives |
| title_fullStr | The role of stem cells in the treatment of retinitis pigmentosa: Contemporary insights and future perspectives |
| title_full_unstemmed | The role of stem cells in the treatment of retinitis pigmentosa: Contemporary insights and future perspectives |
| title_short | The role of stem cells in the treatment of retinitis pigmentosa: Contemporary insights and future perspectives |
| title_sort | role of stem cells in the treatment of retinitis pigmentosa contemporary insights and future perspectives |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/25/bioconf_icbb2025_01002.pdf |
| work_keys_str_mv | AT wangshiqi theroleofstemcellsinthetreatmentofretinitispigmentosacontemporaryinsightsandfutureperspectives AT wangshiqi roleofstemcellsinthetreatmentofretinitispigmentosacontemporaryinsightsandfutureperspectives |