Cyclometalated iridium(III) complex based on isoquinoline alkaloid synergistically elicits the ICD response and IDO inhibition via autophagy-dependent ferroptosis

Cyclometalated iridium(III) complex based on isoquinoline alkaloid synergistically elicits the ICD response and IDO inhibition via autophagy-dependent ferroptosis

The development of anticancer drugs to treat triple-negative breast cancer (TNBC) is an ongoing challenge. Immunogenic cell death (ICD) has garnered considerable interest worldwide as a promising synergistic modality for cancer chemoimmunotherapy. However, only few drugs or treatment modalities can...

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Bibliographic Details
Main Authors: Yuan Lu, Shan-Shan Wang, Meng-Ya Li, Rong Liu, Meng-Fan Zhu, Liang-Mei Yang, Feng-Yang Wang, Ke-Bin Huang, Hong Liang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Organometallic complex
Cyclometalated iridium complex
Isoquinoline alkaloid
ER stress
Autophagy-dependent ferroptosis
Immunogenic cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352400248X
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