CD25bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression

CD25bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression

Infusion of natural killer (NK) cells is an attractive therapeutic modality in patients with cancer. However, the activity of NK cells is regulated by several mechanisms operating within solid tumors. Regulatory T (Treg) cells suppress NK cell activity through various mechanisms including deprivatio...

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Bibliographic Details
Main Authors: Ziqing Chen, Le Tong, Shi Yong Neo, Shuijie Li, Jiwei Gao, Susanne Schlisio, Andreas Lundqvist
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Natural killer cells
regulatory T cells
IL-15
CD25
tumor microenvironment
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2175517
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