Retrospective analysis of cyclosporine A (sandimmun neoral) efficacy and safety in patients with juvenile idiopathic arthritis
Objective. To assess sandimmun neoral (SN) efficacy and safety in pts with juvenile chronic arthritis (JCA). Material and methods. 25 pts (20 girls, 5 boys) aged 3 to 15,5 years (mean 9,7±3,7 years) with JCA were included. 12 from them had systemic and 13 - joint form of the disease. 92% of pts had...
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IMA PRESS LLC
2004-08-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/948 |
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| author | S O Salugina N N Kuzniina |
| author_facet | S O Salugina N N Kuzniina |
| author_sort | S O Salugina |
| collection | DOAJ |
| description | Objective. To assess sandimmun neoral (SN) efficacy and safety in pts with juvenile chronic arthritis (JCA). Material and methods. 25 pts (20 girls, 5 boys) aged 3 to 15,5 years (mean 9,7±3,7 years) with JCA were included. 12 from them had systemic and 13 - joint form of the disease. 92% of pts had polyarthritis and 8% - oligoarthritis. Mean duration of the disease was 5,22+2,5 years (1,5-9,5 years). SN dose varied from 0,5 to 5 mg/kg/day (mean 2,9±l,l mg/kg/day). Treatment duration ranged from 1 month to 5 years. Results. Good and fair effect was achieved in 48% of pts. Swollen joint count significantly decreased particularly after a year of treatment. Laboratory indices of inflammatory activity did not decrease significantly. In 52% of children response to the treatment was unsatisfactory or absent. Half of the pts (52%) had adverse reactions during the treatment with SN. Blood creatinine level elevation was the most significant (8 pts). The reason for the treatment termination was absence of the effect in 8, creatinine elevation - in 2 and financial problems - in 5 pts. Conclusion. Treatment with SN was effective in half of the pts particularly in joint form of JCA.In the whole drug tolerability was good, while half of the pts had adverse reactions which usually did not required treatment termination. |
| format | Article |
| id | doaj-art-e025d5aa45464ea7b0c6f9c27af77f2e |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2004-08-01 |
| publisher | IMA PRESS LLC |
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| series | Научно-практическая ревматология |
| spelling | doaj-art-e025d5aa45464ea7b0c6f9c27af77f2e2025-08-20T03:01:58ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922004-08-01424899110.14412/1995-4484-2004-811888Retrospective analysis of cyclosporine A (sandimmun neoral) efficacy and safety in patients with juvenile idiopathic arthritisS O SaluginaN N KuzniinaObjective. To assess sandimmun neoral (SN) efficacy and safety in pts with juvenile chronic arthritis (JCA). Material and methods. 25 pts (20 girls, 5 boys) aged 3 to 15,5 years (mean 9,7±3,7 years) with JCA were included. 12 from them had systemic and 13 - joint form of the disease. 92% of pts had polyarthritis and 8% - oligoarthritis. Mean duration of the disease was 5,22+2,5 years (1,5-9,5 years). SN dose varied from 0,5 to 5 mg/kg/day (mean 2,9±l,l mg/kg/day). Treatment duration ranged from 1 month to 5 years. Results. Good and fair effect was achieved in 48% of pts. Swollen joint count significantly decreased particularly after a year of treatment. Laboratory indices of inflammatory activity did not decrease significantly. In 52% of children response to the treatment was unsatisfactory or absent. Half of the pts (52%) had adverse reactions during the treatment with SN. Blood creatinine level elevation was the most significant (8 pts). The reason for the treatment termination was absence of the effect in 8, creatinine elevation - in 2 and financial problems - in 5 pts. Conclusion. Treatment with SN was effective in half of the pts particularly in joint form of JCA.In the whole drug tolerability was good, while half of the pts had adverse reactions which usually did not required treatment termination.https://rsp.mediar-press.net/rsp/article/view/948uvenile chronic arthritissandimmun neoral (cyclosporine) |
| spellingShingle | S O Salugina N N Kuzniina Retrospective analysis of cyclosporine A (sandimmun neoral) efficacy and safety in patients with juvenile idiopathic arthritis Научно-практическая ревматология uvenile chronic arthritis sandimmun neoral (cyclosporine) |
| title | Retrospective analysis of cyclosporine A (sandimmun neoral) efficacy and safety in patients with juvenile idiopathic arthritis |
| title_full | Retrospective analysis of cyclosporine A (sandimmun neoral) efficacy and safety in patients with juvenile idiopathic arthritis |
| title_fullStr | Retrospective analysis of cyclosporine A (sandimmun neoral) efficacy and safety in patients with juvenile idiopathic arthritis |
| title_full_unstemmed | Retrospective analysis of cyclosporine A (sandimmun neoral) efficacy and safety in patients with juvenile idiopathic arthritis |
| title_short | Retrospective analysis of cyclosporine A (sandimmun neoral) efficacy and safety in patients with juvenile idiopathic arthritis |
| title_sort | retrospective analysis of cyclosporine a sandimmun neoral efficacy and safety in patients with juvenile idiopathic arthritis |
| topic | uvenile chronic arthritis sandimmun neoral (cyclosporine) |
| url | https://rsp.mediar-press.net/rsp/article/view/948 |
| work_keys_str_mv | AT sosalugina retrospectiveanalysisofcyclosporineasandimmunneoralefficacyandsafetyinpatientswithjuvenileidiopathicarthritis AT nnkuzniina retrospectiveanalysisofcyclosporineasandimmunneoralefficacyandsafetyinpatientswithjuvenileidiopathicarthritis |