Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery
A total of 366 tonsillar tissue samples were collected from healthy free-range pigs owned by farmers across 12 districts in Baise City, Guangxi, China. This initiative successfully isolated six strains of Carbapenem-Resistant Enterobacteriaceae (CRE), including four strains of Escherichia coli, and...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1501997/full |
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| author | Yuan-Yuan Dai Yuan-Yuan Dai Yuan-Yuan Dai Yuan-Yuan Dai Wen-Fei Wei Wen-Fei Wei Xue-zhen Li Chao-Yuan Yuan Li-Juan Zhao Yan-Qiang Huang Yan-Qiang Huang Yan-Qiang Huang Ming Hao Ying Deng Ying Deng Ying Deng Ying Deng Yuan-Ji Teng Yuan-Ji Teng Yuan-Ji Teng Yuan-Ji Teng Xue-Li Yi Xue-Li Yi Xue-Li Yi Xue-Li Yi |
| author_facet | Yuan-Yuan Dai Yuan-Yuan Dai Yuan-Yuan Dai Yuan-Yuan Dai Wen-Fei Wei Wen-Fei Wei Xue-zhen Li Chao-Yuan Yuan Li-Juan Zhao Yan-Qiang Huang Yan-Qiang Huang Yan-Qiang Huang Ming Hao Ying Deng Ying Deng Ying Deng Ying Deng Yuan-Ji Teng Yuan-Ji Teng Yuan-Ji Teng Yuan-Ji Teng Xue-Li Yi Xue-Li Yi Xue-Li Yi Xue-Li Yi |
| author_sort | Yuan-Yuan Dai |
| collection | DOAJ |
| description | A total of 366 tonsillar tissue samples were collected from healthy free-range pigs owned by farmers across 12 districts in Baise City, Guangxi, China. This initiative successfully isolated six strains of Carbapenem-Resistant Enterobacteriaceae (CRE), including four strains of Escherichia coli, and one of Klebsiella aerogenes and Morganella morganii. Assessments utilizing Carbapenemase inhibitor enhancement test, in conjunction with the ResFinder resistance gene database, revealed that five strains carried the blaNDM-5 gene, while one strain possessed the blaNDM-1 gene. The overall positivity rate for CRE was determined to be 1.64%. Conjugation tests further demonstrated the ability of the blaNDM genes to transfer to recipient strains. Additionally, an analysis of the genetic environment surrounding the blaNDM genes showed similarities among the genes within the same geographic region, suggesting that these strains may have originated from a common ancestor and spread horizontally among different clones. This study provides valuable insights into the transmission of CRE among free-range farmers in Baise City, Guangxi, China. |
| format | Article |
| id | doaj-art-e022f3388a8e4672b5a711da83b46c33 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-e022f3388a8e4672b5a711da83b46c332025-08-20T03:52:42ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-05-011210.3389/fvets.2025.15019971501997Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discoveryYuan-Yuan Dai0Yuan-Yuan Dai1Yuan-Yuan Dai2Yuan-Yuan Dai3Wen-Fei Wei4Wen-Fei Wei5Xue-zhen Li6Chao-Yuan Yuan7Li-Juan Zhao8Yan-Qiang Huang9Yan-Qiang Huang10Yan-Qiang Huang11Ming Hao12Ying Deng13Ying Deng14Ying Deng15Ying Deng16Yuan-Ji Teng17Yuan-Ji Teng18Yuan-Ji Teng19Yuan-Ji Teng20Xue-Li Yi21Xue-Li Yi22Xue-Li Yi23Xue-Li Yi24Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, ChinaCenter for Medical Laboratory Science, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, ChinaBaise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Guangxi, ChinaKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Guangxi, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaBaise Center for Animal Disease Prevention and Control, Baise, ChinaBaise Center for Animal Disease Prevention and Control, Baise, ChinaBaise Agriculture and Rural Bureau, Baise, ChinaSchool of Basic Medicine, Youjiang Medical University for Nationalities, Baise, ChinaSchool of Basic Medicine, Youjiang Medical University for Nationalities, Baise, ChinaGuangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areas, Baise, China0Key Laboratory of the Prevention and Treatment of Drug-Resistant Microbial Infecting, Youjiang Medical University for Nationalities, Education Department of Guangxi Zhuang Autonomous Region, Baise, ChinaSchool of Basic Medicine, Youjiang Medical University for Nationalities, Baise, ChinaAffiliated Hospital of Youjiang Medical University for Nationalities, Baise, ChinaCenter for Medical Laboratory Science, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, ChinaBaise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Guangxi, ChinaKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Guangxi, ChinaAffiliated Hospital of Youjiang Medical University for Nationalities, Baise, ChinaCenter for Medical Laboratory Science, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, ChinaBaise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Guangxi, ChinaKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Guangxi, ChinaAffiliated Hospital of Youjiang Medical University for Nationalities, Baise, ChinaCenter for Medical Laboratory Science, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, ChinaBaise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Guangxi, ChinaKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Guangxi, ChinaA total of 366 tonsillar tissue samples were collected from healthy free-range pigs owned by farmers across 12 districts in Baise City, Guangxi, China. This initiative successfully isolated six strains of Carbapenem-Resistant Enterobacteriaceae (CRE), including four strains of Escherichia coli, and one of Klebsiella aerogenes and Morganella morganii. Assessments utilizing Carbapenemase inhibitor enhancement test, in conjunction with the ResFinder resistance gene database, revealed that five strains carried the blaNDM-5 gene, while one strain possessed the blaNDM-1 gene. The overall positivity rate for CRE was determined to be 1.64%. Conjugation tests further demonstrated the ability of the blaNDM genes to transfer to recipient strains. Additionally, an analysis of the genetic environment surrounding the blaNDM genes showed similarities among the genes within the same geographic region, suggesting that these strains may have originated from a common ancestor and spread horizontally among different clones. This study provides valuable insights into the transmission of CRE among free-range farmers in Baise City, Guangxi, China.https://www.frontiersin.org/articles/10.3389/fvets.2025.1501997/fullCREcarbapenemsblaNDMresistance transmissionswine |
| spellingShingle | Yuan-Yuan Dai Yuan-Yuan Dai Yuan-Yuan Dai Yuan-Yuan Dai Wen-Fei Wei Wen-Fei Wei Xue-zhen Li Chao-Yuan Yuan Li-Juan Zhao Yan-Qiang Huang Yan-Qiang Huang Yan-Qiang Huang Ming Hao Ying Deng Ying Deng Ying Deng Ying Deng Yuan-Ji Teng Yuan-Ji Teng Yuan-Ji Teng Yuan-Ji Teng Xue-Li Yi Xue-Li Yi Xue-Li Yi Xue-Li Yi Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery Frontiers in Veterinary Science CRE carbapenems blaNDM resistance transmission swine |
| title | Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery |
| title_full | Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery |
| title_fullStr | Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery |
| title_full_unstemmed | Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery |
| title_short | Emergence and transmission of Carbapenem-resistant Enterobacteriaceae blaNDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery |
| title_sort | emergence and transmission of carbapenem resistant enterobacteriaceae blandm 5 gene in healthy pigs in baise guangxi china a discovery |
| topic | CRE carbapenems blaNDM resistance transmission swine |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1501997/full |
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