Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization
Benchtop Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique for the monitoring of reactions and processes due to its accessibility and lower cost compared to high-field NMR. However, benchtop NMR spectroscopy often suffers from limited sensitivity and resolution. In thi...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Magnetic Resonance Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666441025000111 |
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| author | Joris Mandral Johnnie Phuong Jonathan Farjon Patrick Giraudeau Kerstin Münnemann Jean-Nicolas Dumez |
| author_facet | Joris Mandral Johnnie Phuong Jonathan Farjon Patrick Giraudeau Kerstin Münnemann Jean-Nicolas Dumez |
| author_sort | Joris Mandral |
| collection | DOAJ |
| description | Benchtop Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique for the monitoring of reactions and processes due to its accessibility and lower cost compared to high-field NMR. However, benchtop NMR spectroscopy often suffers from limited sensitivity and resolution. In this work, we have combined ultrafast (UF) 2D NMR with Overhauser Dynamic Nuclear Polarization (ODNP) to tackle both problems. Compared to thermally polarized 1D NMR, UF 2D NMR provides improved spectral resolution in a single scan whereas ODNP boosts the NMR sensitivity. To demonstrate the possibility of combining UF 2D NMR with ODNP for process monitoring applications, experiments were carried out at different flow conditions. Our results show that ODNP at least compensated for the losses in sensitivity of UF 2D NMR that are normally induced by high flow velocities. Moreover, under certain flow conditions, ODNP brings additional sensitivity to UF 2D NMR spectra, with SNR increased by a factor of >3 compared to thermal equilibrium acquisitions. The methods developed in this article are expected to be beneficial for more informative and sensitive acquisitions in the context of process monitoring. |
| format | Article |
| id | doaj-art-e01ec3db55884671af2a0ef9e8a8848d |
| institution | OA Journals |
| issn | 2666-4410 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Magnetic Resonance Open |
| spelling | doaj-art-e01ec3db55884671af2a0ef9e8a8848d2025-08-20T02:05:36ZengElsevierJournal of Magnetic Resonance Open2666-44102025-06-012310019510.1016/j.jmro.2025.100195Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarizationJoris Mandral0Johnnie Phuong1Jonathan Farjon2Patrick Giraudeau3Kerstin Münnemann4Jean-Nicolas Dumez5Nantes Université, CNRS, CEISAM UMR6230, F-44000, Nantes, FranceLaboratory of Engineering Thermodynamics (LTD), RPTU Kaiserslautern D-67663, Kaiserslautern, Germany; Laboratory of Advanced Spin Engineering – Magnetic Resonance (LASE-MR), RPTU Kaiserslautern D-67663, Kaiserslautern, GermanyNantes Université, CNRS, CEISAM UMR6230, F-44000, Nantes, FranceNantes Université, CNRS, CEISAM UMR6230, F-44000, Nantes, FranceLaboratory of Engineering Thermodynamics (LTD), RPTU Kaiserslautern D-67663, Kaiserslautern, Germany; Laboratory of Advanced Spin Engineering – Magnetic Resonance (LASE-MR), RPTU Kaiserslautern D-67663, Kaiserslautern, Germany; Corresponding authors.Nantes Université, CNRS, CEISAM UMR6230, F-44000, Nantes, France; Corresponding authors.Benchtop Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique for the monitoring of reactions and processes due to its accessibility and lower cost compared to high-field NMR. However, benchtop NMR spectroscopy often suffers from limited sensitivity and resolution. In this work, we have combined ultrafast (UF) 2D NMR with Overhauser Dynamic Nuclear Polarization (ODNP) to tackle both problems. Compared to thermally polarized 1D NMR, UF 2D NMR provides improved spectral resolution in a single scan whereas ODNP boosts the NMR sensitivity. To demonstrate the possibility of combining UF 2D NMR with ODNP for process monitoring applications, experiments were carried out at different flow conditions. Our results show that ODNP at least compensated for the losses in sensitivity of UF 2D NMR that are normally induced by high flow velocities. Moreover, under certain flow conditions, ODNP brings additional sensitivity to UF 2D NMR spectra, with SNR increased by a factor of >3 compared to thermal equilibrium acquisitions. The methods developed in this article are expected to be beneficial for more informative and sensitive acquisitions in the context of process monitoring.http://www.sciencedirect.com/science/article/pii/S2666441025000111Overhauser DNPUltrafast NMRFlow NMR |
| spellingShingle | Joris Mandral Johnnie Phuong Jonathan Farjon Patrick Giraudeau Kerstin Münnemann Jean-Nicolas Dumez Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization Journal of Magnetic Resonance Open Overhauser DNP Ultrafast NMR Flow NMR |
| title | Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization |
| title_full | Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization |
| title_fullStr | Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization |
| title_full_unstemmed | Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization |
| title_short | Ultrafast 2D benchtop NMR spectroscopy enhanced by flow Overhauser dynamic nuclear polarization |
| title_sort | ultrafast 2d benchtop nmr spectroscopy enhanced by flow overhauser dynamic nuclear polarization |
| topic | Overhauser DNP Ultrafast NMR Flow NMR |
| url | http://www.sciencedirect.com/science/article/pii/S2666441025000111 |
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