Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation
Thyroid heterotopic bone formation (HBF) in goiter is a rare finding. Five thyroid resection specimens were analyzed for HBF. The results were correlated with clinicomorphological features. All patients were women (33–82 years). The preoperative diagnosis was thyroid goiter or nodule. Treatment cons...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/806864 |
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| author | Adriana Handra-Luca Marie-Laure Dumuis-Gimenez Mouna Bendib Panagiotis Anagnostis |
| author_facet | Adriana Handra-Luca Marie-Laure Dumuis-Gimenez Mouna Bendib Panagiotis Anagnostis |
| author_sort | Adriana Handra-Luca |
| collection | DOAJ |
| description | Thyroid heterotopic bone formation (HBF) in goiter is a rare finding. Five thyroid resection specimens were analyzed for HBF. The results were correlated with clinicomorphological features. All patients were women (33–82 years). The preoperative diagnosis was thyroid goiter or nodule. Treatment consisted in thyroidectomy and lobectomy (3 and 2, resp.). Microscopy showed sporadic nodular goiter. Malformative blood vessels and vascular calcifications were seen in intra- and extrathyroid location (5 and 3, resp.). The number and size of HBFs (total: 28) ranged between 1 and 23/thyroid gland (one bilateral) and 1 and 10 mm, respectively. Twelve HBFs were in contact with the thyroid capsule. Most were extranodular (21, versus 6 intranodular). The medical history was positive for dyslipidemia, hyperglycemia, renal dysfunction, and hyperuricemia (2, 3, and 3 cases and 1 case, resp.) without any parathyroid abnormality. In conclusion, thyroid HBF may be characterized by subcapsular or extranodular location, various size (usually ≥2 mm), and vascular calcifications and malformations. Features of metabolic syndrome and renal dysfunction may be present, but their exact role in the pathogenesis of HBFs remains to be elucidated. |
| format | Article |
| id | doaj-art-e01a7ff3934d4dd8b9abb3622ce393ce |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-e01a7ff3934d4dd8b9abb3622ce393ce2025-08-20T03:26:05ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/806864806864Thyroid Sporadic Goiter with Adult Heterotopic Bone FormationAdriana Handra-Luca0Marie-Laure Dumuis-Gimenez1Mouna Bendib2Panagiotis Anagnostis3Service d’Anatomie Pathologique, APHP GHU Avicenne, UFR Médecine, Université Paris Nord Sorbonne Cité, 125 rue Stalingrad, 93009 Bobigny, FranceService Medecine Nucleaire, APHP GHU Avicenne, 93009 Bobigny, FranceService d’Anatomie Pathologique, APHP GHU Avicenne, UFR Médecine, Université Paris Nord Sorbonne Cité, 125 rue Stalingrad, 93009 Bobigny, FranceDivision of Endocrinology, Police Medical Centre, Monastiriou 326, 54627 Thessaloniki, GreeceThyroid heterotopic bone formation (HBF) in goiter is a rare finding. Five thyroid resection specimens were analyzed for HBF. The results were correlated with clinicomorphological features. All patients were women (33–82 years). The preoperative diagnosis was thyroid goiter or nodule. Treatment consisted in thyroidectomy and lobectomy (3 and 2, resp.). Microscopy showed sporadic nodular goiter. Malformative blood vessels and vascular calcifications were seen in intra- and extrathyroid location (5 and 3, resp.). The number and size of HBFs (total: 28) ranged between 1 and 23/thyroid gland (one bilateral) and 1 and 10 mm, respectively. Twelve HBFs were in contact with the thyroid capsule. Most were extranodular (21, versus 6 intranodular). The medical history was positive for dyslipidemia, hyperglycemia, renal dysfunction, and hyperuricemia (2, 3, and 3 cases and 1 case, resp.) without any parathyroid abnormality. In conclusion, thyroid HBF may be characterized by subcapsular or extranodular location, various size (usually ≥2 mm), and vascular calcifications and malformations. Features of metabolic syndrome and renal dysfunction may be present, but their exact role in the pathogenesis of HBFs remains to be elucidated.http://dx.doi.org/10.1155/2015/806864 |
| spellingShingle | Adriana Handra-Luca Marie-Laure Dumuis-Gimenez Mouna Bendib Panagiotis Anagnostis Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation Case Reports in Endocrinology |
| title | Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation |
| title_full | Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation |
| title_fullStr | Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation |
| title_full_unstemmed | Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation |
| title_short | Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation |
| title_sort | thyroid sporadic goiter with adult heterotopic bone formation |
| url | http://dx.doi.org/10.1155/2015/806864 |
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