Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading

Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading

Abstract Depression has been widely recognized as an important accelerating factor contributing to the aggravation of cognitive decline in Alzheimer’s disease (AD) patients. Previous studies show that microglia-mediated neuroinflammation is a common and critical event in the etiology of both depress...

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Bibliographic Details
Main Authors: Xiaoli Liu, Huijin Wang, Xi Tian, Yingqi Luo, Minmin Ma, Zilong Zheng, Yaping Wang, Shi Feng, Qiushi Wang, Zhuo Xu, Wen Yao, Siqiang Ren
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Neuroinflammation
Subjects:
Depression
Alzheimer’s disease
Kv1.3
Lactate
Exosomes
Aβ spreading
Online Access:https://doi.org/10.1186/s12974-025-03488-2
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