PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway

PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway

Abstract Background Renal cell carcinoma (RCC) is a frequent and aggressive type of kidney cancer with limited therapeutic options. Although phosphatase and tensin homolog (PTEN) have been recognized as a potential tumor suppressor in all kinds of cancers, its function in RCC remains to be thoroughl...

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Bibliographic Details
Main Authors: Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen
Format: Article
Language:English
Published: BMC 2025-02-01
Series:World Journal of Surgical Oncology
Subjects:
PTEN
PI3K/AKT pathway
Renal cell carcinoma
Cell proliferation
Cell migration
Online Access:https://doi.org/10.1186/s12957-025-03658-9
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