Sex differences in diet-induced MASLD – are female mice naturally protected?

Sex differences in diet-induced MASLD – are female mice naturally protected?

Males suffer more often from profibrotic changes in liver than females. The underlying mechanism for this sex difference in the prevalence and manifestation of Metabolic dysfunction-associated Steatotic Liver Disease (MASLD) is not yet completely known. We studied male and female mice that were indu...

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Main Authors: Jana Meyer, Ana Mendes Teixeira, Sandy Richter, Dean P. Larner, Asifuddin Syed, Nora Klöting, Madlen Matz-Soja, Susanne Gaul, Anja Barnikol-Oettler, Wieland Kiess, Diana Le Duc, Melanie Penke, Antje Garten
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Endocrinology
Subjects:
MAFLD
NAFLD
high fat diet
adipose tissue
fibrosis
estrogen
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1567573/full
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