Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial
BackgroundProlonged disorders of consciousness (pDoC) resulting from intracerebral hemorrhage (ICH) significantly impair patients’ quality of life. This study aims to investigate the therapeutic effects of transcranial direct current stimulation (tDCS) combined with median nerve stimulation (MNS) in...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1497316/full |
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| author | Hanbo Chen Shujuan Huang Si Chen Zitian Wang Yong Luo Yongliang Guo Weifeng Wen Jinfeng Liang Yunhong Deng Xiao Lv |
| author_facet | Hanbo Chen Shujuan Huang Si Chen Zitian Wang Yong Luo Yongliang Guo Weifeng Wen Jinfeng Liang Yunhong Deng Xiao Lv |
| author_sort | Hanbo Chen |
| collection | DOAJ |
| description | BackgroundProlonged disorders of consciousness (pDoC) resulting from intracerebral hemorrhage (ICH) significantly impair patients’ quality of life. This study aims to investigate the therapeutic effects of transcranial direct current stimulation (tDCS) combined with median nerve stimulation (MNS) in patients with pDoC 3–12 months post-ICH.MethodsThis prospective, double-blind, randomized controlled trial will enroll 138 eligible patients with pDoC following ICH. Participants will be randomly assigned to three groups of 27 each: (1) tDCS + MNS, (2) sham tDCS + MNS, and (3) tDCS + sham MNS. The intervention will last for 4 weeks, followed by a 6-month follow-up period. The primary outcome measure is the change in the Coma Recovery Scale-Revised (CRS-R) scores. Secondary outcomes include electrophysiological and neuroimaging data. Assessments will be conducted at baseline, after 4 weeks of treatment, and at 2 weeks, 4 weeks, 12 weeks, and 24 weeks post-intervention.DiscussionThe strengths of this study include the combined intervention approach of tDCS and MNS, as well as comprehensive outcome measures. This intervention may promote consciousness recovery through multiple mechanisms, including enhanced neuroplasticity and modulation of brain networks. This study aims to provide a novel approach for consciousness-promoting treatment in pDoC, potentially improving patient prognosis and quality of life.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=203618, identifier ChiCTR2300075190. |
| format | Article |
| id | doaj-art-e014363b416b427e8b2a354512cc5ca0 |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-e014363b416b427e8b2a354512cc5ca02025-08-20T02:34:15ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-06-011610.3389/fneur.2025.14973161497316Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trialHanbo Chen0Shujuan Huang1Si Chen2Zitian Wang3Yong Luo4Yongliang Guo5Weifeng Wen6Jinfeng Liang7Yunhong Deng8Xiao Lv9Department of Rehabilitation Therapy, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaDepartment of Rehabilitation Therapy, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaDepartment of Rehabilitation Therapy, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaZhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Rehabilitation Therapy, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaDepartment of Rehabilitation Therapy, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaDepartment of Rehabilitation Therapy, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaDepartment of Rehabilitation Therapy, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaDepartment of Rehabilitation Therapy, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Guangdong Sanjiu Brain Hospital, Guangzhou, ChinaBackgroundProlonged disorders of consciousness (pDoC) resulting from intracerebral hemorrhage (ICH) significantly impair patients’ quality of life. This study aims to investigate the therapeutic effects of transcranial direct current stimulation (tDCS) combined with median nerve stimulation (MNS) in patients with pDoC 3–12 months post-ICH.MethodsThis prospective, double-blind, randomized controlled trial will enroll 138 eligible patients with pDoC following ICH. Participants will be randomly assigned to three groups of 27 each: (1) tDCS + MNS, (2) sham tDCS + MNS, and (3) tDCS + sham MNS. The intervention will last for 4 weeks, followed by a 6-month follow-up period. The primary outcome measure is the change in the Coma Recovery Scale-Revised (CRS-R) scores. Secondary outcomes include electrophysiological and neuroimaging data. Assessments will be conducted at baseline, after 4 weeks of treatment, and at 2 weeks, 4 weeks, 12 weeks, and 24 weeks post-intervention.DiscussionThe strengths of this study include the combined intervention approach of tDCS and MNS, as well as comprehensive outcome measures. This intervention may promote consciousness recovery through multiple mechanisms, including enhanced neuroplasticity and modulation of brain networks. This study aims to provide a novel approach for consciousness-promoting treatment in pDoC, potentially improving patient prognosis and quality of life.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=203618, identifier ChiCTR2300075190.https://www.frontiersin.org/articles/10.3389/fneur.2025.1497316/fulltranscranial direct current stimulationmedian nerve stimulationprolonged disorders of consciousnessCRS-Rprotocol |
| spellingShingle | Hanbo Chen Shujuan Huang Si Chen Zitian Wang Yong Luo Yongliang Guo Weifeng Wen Jinfeng Liang Yunhong Deng Xiao Lv Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial Frontiers in Neurology transcranial direct current stimulation median nerve stimulation prolonged disorders of consciousness CRS-R protocol |
| title | Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial |
| title_full | Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial |
| title_fullStr | Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial |
| title_full_unstemmed | Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial |
| title_short | Impact of transcranial direct current stimulation combined with median nerve stimulation on CRS-R in patients with prolonged disorders of consciousness after cerebral hemorrhage: protocol for a randomized controlled trial |
| title_sort | impact of transcranial direct current stimulation combined with median nerve stimulation on crs r in patients with prolonged disorders of consciousness after cerebral hemorrhage protocol for a randomized controlled trial |
| topic | transcranial direct current stimulation median nerve stimulation prolonged disorders of consciousness CRS-R protocol |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1497316/full |
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