Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang
BACKGROUND: Transfusion support is vital for the management of patients with hepatobiliary disease. Repeated blood transfusions increase the risk of alloimmunization, i.e., the development of alloantibodies, which might lead to difficulties in blood crossmatching. AIMS: This study aims to: (1) deter...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_75_22 |
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| author | Prasanthini Nahendran Siti Balkis Budin Nur Zakiah Mohd Saat Mohd Faeiz Yusop Tengku Norita Tengku Yazid Nur Najmi Mohamad Anuar |
| author_facet | Prasanthini Nahendran Siti Balkis Budin Nur Zakiah Mohd Saat Mohd Faeiz Yusop Tengku Norita Tengku Yazid Nur Najmi Mohamad Anuar |
| author_sort | Prasanthini Nahendran |
| collection | DOAJ |
| description | BACKGROUND:
Transfusion support is vital for the management of patients with hepatobiliary disease. Repeated blood transfusions increase the risk of alloimmunization, i.e., the development of alloantibodies, which might lead to difficulties in blood crossmatching.
AIMS:
This study aims to: (1) determine the incidence of red blood cell (RBC) alloimmunization and (2) evaluate the associations between antibody development and demographic factors among hepatobiliary patients.
METHOD:
ABO blood grouping, antibody screening, antibody identification and crossmatch were done on all patients samples included in the study.
SETTINGS AND DESIGN:
A cross-sectional study was conducted from February 2021 to September 2021, with a total of 132 samples from hepatobiliary patients. The relationships between RBC alloimmunization in transfused hepatobiliary patients and demographic factors (gender, age, and history of transfusion) were assessed by binary logistic regression.
RESULTS:
Overall, 67.4% of the patients developed alloimmunization. The majority had a single alloantibody (75.2%) and the most frequently identified antibody specificities were anti-E (37.6%), anti-c (12.8%), anti-Mia (14.4%), and anti-Kidd (11.2%). The predominant antibodies were those against the Rh system (58.4%). Female patients recorded the highest incidence of alloimmunization (69.8%). Female patients also demonstrated a higher tendency to produce both anti-E + anti-c than male patients.
CONCLUSION:
The prevalence of RBC alloimmunization is high among hepatobiliary patients and it may cause complications requiring multiple transfusions. The number of transfused packed cells has been clearly shown to be proportionally significant with the risk for alloimmunization in hepatobiliary patients. Hence, this study highlights the importance of immunohematology tests before blood transfusion. |
| format | Article |
| id | doaj-art-e012a65502ba48baa19581a48c0434b3 |
| institution | OA Journals |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-e012a65502ba48baa19581a48c0434b32025-08-20T02:36:53ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652024-12-0118228629010.4103/ajts.ajts_75_22Red cell alloimmunization in multitransfused hepatobiliary patients at hospital SelayangPrasanthini NahendranSiti Balkis BudinNur Zakiah Mohd SaatMohd Faeiz YusopTengku Norita Tengku YazidNur Najmi Mohamad AnuarBACKGROUND: Transfusion support is vital for the management of patients with hepatobiliary disease. Repeated blood transfusions increase the risk of alloimmunization, i.e., the development of alloantibodies, which might lead to difficulties in blood crossmatching. AIMS: This study aims to: (1) determine the incidence of red blood cell (RBC) alloimmunization and (2) evaluate the associations between antibody development and demographic factors among hepatobiliary patients. METHOD: ABO blood grouping, antibody screening, antibody identification and crossmatch were done on all patients samples included in the study. SETTINGS AND DESIGN: A cross-sectional study was conducted from February 2021 to September 2021, with a total of 132 samples from hepatobiliary patients. The relationships between RBC alloimmunization in transfused hepatobiliary patients and demographic factors (gender, age, and history of transfusion) were assessed by binary logistic regression. RESULTS: Overall, 67.4% of the patients developed alloimmunization. The majority had a single alloantibody (75.2%) and the most frequently identified antibody specificities were anti-E (37.6%), anti-c (12.8%), anti-Mia (14.4%), and anti-Kidd (11.2%). The predominant antibodies were those against the Rh system (58.4%). Female patients recorded the highest incidence of alloimmunization (69.8%). Female patients also demonstrated a higher tendency to produce both anti-E + anti-c than male patients. CONCLUSION: The prevalence of RBC alloimmunization is high among hepatobiliary patients and it may cause complications requiring multiple transfusions. The number of transfused packed cells has been clearly shown to be proportionally significant with the risk for alloimmunization in hepatobiliary patients. Hence, this study highlights the importance of immunohematology tests before blood transfusion.https://journals.lww.com/10.4103/ajts.ajts_75_22alloantibodiesalloimmunizationclinically significanthepatobiliarytransfusion |
| spellingShingle | Prasanthini Nahendran Siti Balkis Budin Nur Zakiah Mohd Saat Mohd Faeiz Yusop Tengku Norita Tengku Yazid Nur Najmi Mohamad Anuar Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang Asian Journal of Transfusion Science alloantibodies alloimmunization clinically significant hepatobiliary transfusion |
| title | Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang |
| title_full | Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang |
| title_fullStr | Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang |
| title_full_unstemmed | Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang |
| title_short | Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang |
| title_sort | red cell alloimmunization in multitransfused hepatobiliary patients at hospital selayang |
| topic | alloantibodies alloimmunization clinically significant hepatobiliary transfusion |
| url | https://journals.lww.com/10.4103/ajts.ajts_75_22 |
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