Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis
Abstract Introduction This meta-analysis aims to find the relationship of ESR-1 gene polymorphisms (rs1801132, rs2228480, and rs2234693) with migraine risk among Caucasian and Asian populations. Methods To perform the present meta-analysis a search was carried out across several databases. The data...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-11-01
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| Series: | Egyptian Journal of Medical Human Genetics |
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| Online Access: | https://doi.org/10.1186/s43042-024-00607-1 |
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| author | Sharon Benita Stephen Jayakanthan Saravanan Gurudeva Chandrashekar Gowtham Kumar Subbaraj |
| author_facet | Sharon Benita Stephen Jayakanthan Saravanan Gurudeva Chandrashekar Gowtham Kumar Subbaraj |
| author_sort | Sharon Benita Stephen |
| collection | DOAJ |
| description | Abstract Introduction This meta-analysis aims to find the relationship of ESR-1 gene polymorphisms (rs1801132, rs2228480, and rs2234693) with migraine risk among Caucasian and Asian populations. Methods To perform the present meta-analysis a search was carried out across several databases. The data obtained from the databases were analysed statistically using Review Manager 5.4 and MetaGenyo software. A total of 20 case–control studies were selected among them 12 articles were consisting of seven articles belonging to rs1801132, five articles belonging to rs2228480, and six articles belonging to rs2234693 for revealing the relationship between ESR-1 gene polymorphisms (rs1801132, rs2228480, and rs2234693) and migraine risk. The protocol for the present meta-analysis was registered (PROSPERO ID Number: 441920). Results A total of 20 articles were included in this meta-analysis. According to the findings of this study, people with ESR-1 (rs1801132, rs2228480, and rs2234693 did not show an association with migraine risk in the allelic, recessive, dominant, and over-dominant models. Conclusion However, the results from the present meta-analysis are conflicting from the previously meta-analysis reports. Further research is needed to unravel the complex genetic basis of this debilitating condition. |
| format | Article |
| id | doaj-art-e0116dc515c049c88b462b31b7925ea8 |
| institution | DOAJ |
| issn | 2090-2441 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj-art-e0116dc515c049c88b462b31b7925ea82025-08-20T02:39:35ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412024-11-0125111510.1186/s43042-024-00607-1Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysisSharon Benita Stephen0Jayakanthan Saravanan1Gurudeva Chandrashekar2Gowtham Kumar Subbaraj3Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and EducationDepartment of General Surgery, Sree Balaji Medical College and HospitalDepartment of Pharmacology, Karuna Medical CollegeFaculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and EducationAbstract Introduction This meta-analysis aims to find the relationship of ESR-1 gene polymorphisms (rs1801132, rs2228480, and rs2234693) with migraine risk among Caucasian and Asian populations. Methods To perform the present meta-analysis a search was carried out across several databases. The data obtained from the databases were analysed statistically using Review Manager 5.4 and MetaGenyo software. A total of 20 case–control studies were selected among them 12 articles were consisting of seven articles belonging to rs1801132, five articles belonging to rs2228480, and six articles belonging to rs2234693 for revealing the relationship between ESR-1 gene polymorphisms (rs1801132, rs2228480, and rs2234693) and migraine risk. The protocol for the present meta-analysis was registered (PROSPERO ID Number: 441920). Results A total of 20 articles were included in this meta-analysis. According to the findings of this study, people with ESR-1 (rs1801132, rs2228480, and rs2234693 did not show an association with migraine risk in the allelic, recessive, dominant, and over-dominant models. Conclusion However, the results from the present meta-analysis are conflicting from the previously meta-analysis reports. Further research is needed to unravel the complex genetic basis of this debilitating condition.https://doi.org/10.1186/s43042-024-00607-1ESR-1Gene polymorphismMigraineGenetic susceptibilityHeadacheMeta-analysis |
| spellingShingle | Sharon Benita Stephen Jayakanthan Saravanan Gurudeva Chandrashekar Gowtham Kumar Subbaraj Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis Egyptian Journal of Medical Human Genetics ESR-1 Gene polymorphism Migraine Genetic susceptibility Headache Meta-analysis |
| title | Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis |
| title_full | Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis |
| title_fullStr | Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis |
| title_full_unstemmed | Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis |
| title_short | Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis |
| title_sort | association between estrogen receptor 1 gene polymorphisms rs1801132 rs2228480 rs2234693 and migraine susceptibility an unveiling association through a comprehensive meta analysis |
| topic | ESR-1 Gene polymorphism Migraine Genetic susceptibility Headache Meta-analysis |
| url | https://doi.org/10.1186/s43042-024-00607-1 |
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