Research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancer
Gastric cancer (GC) remains a major global public health concern, with approximately 969000 new cases diagnosed worldwide in 2022, of which China accounted for 37%. Its incidence exhibits significant regional disparities and is closely linked to environmental factors. External environmental exposure...
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| Format: | Article |
| Language: | zho |
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Lanzhou University Press
2025-06-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20250206?st=article_issue |
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| _version_ | 1849702276174708736 |
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| author | Zhang Mingyue Wu Chuanqing |
| author_facet | Zhang Mingyue Wu Chuanqing |
| author_sort | Zhang Mingyue |
| collection | DOAJ |
| description | Gastric cancer (GC) remains a major global public health concern, with approximately 969000 new cases diagnosed worldwide in 2022, of which China accounted for 37%. Its incidence exhibits significant regional disparities and is closely linked to environmental factors. External environmental exposures, including poor dietary habits, smoking, and industrial pollution, contribute to carcinogenesis by disrupting the gastric mucosal barrier, inducing inflammation, and causing DNA damage. Internal environmental factors, such as Helicobacter pylori infection and gut microbiota dysbiosis, further exacerbate GC progression by activating oncogenic signaling pathways and reprogramming cellular metabolism. This review systematically analyzes and summarizes how these key environmental factors drive gastric carcinogenesis, providing a theoretical basis and practical direction for its prevention, early screening, and personalized treatment. |
| format | Article |
| id | doaj-art-e00ed63cf726407f916f1b9c438317f3 |
| institution | DOAJ |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-e00ed63cf726407f916f1b9c438317f32025-08-20T03:17:43ZzhoLanzhou University Press生物医学转化2096-89652025-06-0162313810.12287/j.issn.2096-8965.20250205Research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancerZhang Mingyue0Wu Chuanqing1Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 , Hubei, ChinaDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 , Hubei, ChinaGastric cancer (GC) remains a major global public health concern, with approximately 969000 new cases diagnosed worldwide in 2022, of which China accounted for 37%. Its incidence exhibits significant regional disparities and is closely linked to environmental factors. External environmental exposures, including poor dietary habits, smoking, and industrial pollution, contribute to carcinogenesis by disrupting the gastric mucosal barrier, inducing inflammation, and causing DNA damage. Internal environmental factors, such as Helicobacter pylori infection and gut microbiota dysbiosis, further exacerbate GC progression by activating oncogenic signaling pathways and reprogramming cellular metabolism. This review systematically analyzes and summarizes how these key environmental factors drive gastric carcinogenesis, providing a theoretical basis and practical direction for its prevention, early screening, and personalized treatment.http://swyxzh.ijournals.cn/swyxzh/article/html/20250206?st=article_issuegastric cancerenvironmental exposureenvironmental oncologycancer prevention and controlhelicobacter pylori |
| spellingShingle | Zhang Mingyue Wu Chuanqing Research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancer 生物医学转化 gastric cancer environmental exposure environmental oncology cancer prevention and control helicobacter pylori |
| title | Research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancer |
| title_full | Research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancer |
| title_fullStr | Research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancer |
| title_full_unstemmed | Research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancer |
| title_short | Research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancer |
| title_sort | research progress on key environmental drivers and comprehensive prevention and control strategies of gastric cancer |
| topic | gastric cancer environmental exposure environmental oncology cancer prevention and control helicobacter pylori |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20250206?st=article_issue |
| work_keys_str_mv | AT zhangmingyue researchprogressonkeyenvironmentaldriversandcomprehensivepreventionandcontrolstrategiesofgastriccancer AT wuchuanqing researchprogressonkeyenvironmentaldriversandcomprehensivepreventionandcontrolstrategiesofgastriccancer |