Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia
Abstract 374 pregnant women with isolated hypothyroxinemia (IH) who were ≤ 20 weeks were included retrospectively in this study. Based on the confirmed gestational age and the use of levothyroxine (LT4), the patients were divided into the treated group (T1 group) and untreated group (C1 group) in fi...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84866-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850258885864062976 |
|---|---|
| author | Dong Liu Yajuan Xu Jingjing Li Xin Tian Lin Hu Zongzong Sun Yanjie Ban Miao Zhang Lulu Hu Chenchen Zhang Yixin Wang Pengkun Lin |
| author_facet | Dong Liu Yajuan Xu Jingjing Li Xin Tian Lin Hu Zongzong Sun Yanjie Ban Miao Zhang Lulu Hu Chenchen Zhang Yixin Wang Pengkun Lin |
| author_sort | Dong Liu |
| collection | DOAJ |
| description | Abstract 374 pregnant women with isolated hypothyroxinemia (IH) who were ≤ 20 weeks were included retrospectively in this study. Based on the confirmed gestational age and the use of levothyroxine (LT4), the patients were divided into the treated group (T1 group) and untreated group (C1 group) in first trimester (≤ 13+ 6 weeks), the treated group(T2 group) and untreated group (C2 group) in second trimester (14–20 weeks). Data on thyroid function and lipid indices was collected both before and after LT4 treatment. To compare the thyroid function, lipid indices and pregnancy outcomes after LT4 treatment. There was a negative correlation between FT4 levels and TC and LDL levels in the first trimester (P<0.05). FT4 and HDL levels in T1 group were significantly increased, and TSH, TC, TG and LDL levels were decreased, compared to C1 group (P < 0.05). FT4 levels in T2 group were higher than C2 group, and there was no significant difference in other indicators. The risk of spontaneous abortion, gestational diabetes mellitus (GDM) and macrosomia in T1 group was significantly decreased (P < 0.05), and there was no significant difference between T2 and C2 groups. Thus, LT4 treatment can improve the level of FT4 and lipids and reduce adverse pregnancy outcomes in women with IH in the first trimester. |
| format | Article |
| id | doaj-art-e00b1df15e1a498f8021d9e881ddb806 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e00b1df15e1a498f8021d9e881ddb8062025-08-20T01:56:01ZengNature PortfolioScientific Reports2045-23222025-04-011511810.1038/s41598-024-84866-3Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemiaDong Liu0Yajuan Xu1Jingjing Li2Xin Tian3Lin Hu4Zongzong Sun5Yanjie Ban6Miao Zhang7Lulu Hu8Chenchen Zhang9Yixin Wang10Pengkun Lin11Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou UniversityAbstract 374 pregnant women with isolated hypothyroxinemia (IH) who were ≤ 20 weeks were included retrospectively in this study. Based on the confirmed gestational age and the use of levothyroxine (LT4), the patients were divided into the treated group (T1 group) and untreated group (C1 group) in first trimester (≤ 13+ 6 weeks), the treated group(T2 group) and untreated group (C2 group) in second trimester (14–20 weeks). Data on thyroid function and lipid indices was collected both before and after LT4 treatment. To compare the thyroid function, lipid indices and pregnancy outcomes after LT4 treatment. There was a negative correlation between FT4 levels and TC and LDL levels in the first trimester (P<0.05). FT4 and HDL levels in T1 group were significantly increased, and TSH, TC, TG and LDL levels were decreased, compared to C1 group (P < 0.05). FT4 levels in T2 group were higher than C2 group, and there was no significant difference in other indicators. The risk of spontaneous abortion, gestational diabetes mellitus (GDM) and macrosomia in T1 group was significantly decreased (P < 0.05), and there was no significant difference between T2 and C2 groups. Thus, LT4 treatment can improve the level of FT4 and lipids and reduce adverse pregnancy outcomes in women with IH in the first trimester.https://doi.org/10.1038/s41598-024-84866-3HypothyroxinemiaLipidsLevothyroxinePregnancy outcomes |
| spellingShingle | Dong Liu Yajuan Xu Jingjing Li Xin Tian Lin Hu Zongzong Sun Yanjie Ban Miao Zhang Lulu Hu Chenchen Zhang Yixin Wang Pengkun Lin Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia Scientific Reports Hypothyroxinemia Lipids Levothyroxine Pregnancy outcomes |
| title | Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia |
| title_full | Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia |
| title_fullStr | Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia |
| title_full_unstemmed | Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia |
| title_short | Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia |
| title_sort | effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia |
| topic | Hypothyroxinemia Lipids Levothyroxine Pregnancy outcomes |
| url | https://doi.org/10.1038/s41598-024-84866-3 |
| work_keys_str_mv | AT dongliu effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT yajuanxu effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT jingjingli effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT xintian effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT linhu effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT zongzongsun effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT yanjieban effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT miaozhang effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT luluhu effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT chenchenzhang effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT yixinwang effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia AT pengkunlin effectoflevothyroxinetreatmentonserumlipidsandpregnancyoutcomesinpregnantwomenwithisolatedhypothyroxinemia |