Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage disease
Objective The current treatment for early-stage neuroendocrine carcinoma of the cervix (NECC) mainly relies on operation and chemotherapy. We want to evaluate values of postoperative radiation in early-stage NECC.Methods Retrospective cohort study. Early-stage NECC patients from 2006 to 2022 in our...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2466667 |
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| author | Xiaochen Song Hui Zhang Sen Zhong Xianjie Tan Shuiqing Ma Ying Jin Lingya Pan Ming Wu Dongyan Cao Jiaxin Yang Yang Xiang |
| author_facet | Xiaochen Song Hui Zhang Sen Zhong Xianjie Tan Shuiqing Ma Ying Jin Lingya Pan Ming Wu Dongyan Cao Jiaxin Yang Yang Xiang |
| author_sort | Xiaochen Song |
| collection | DOAJ |
| description | Objective The current treatment for early-stage neuroendocrine carcinoma of the cervix (NECC) mainly relies on operation and chemotherapy. We want to evaluate values of postoperative radiation in early-stage NECC.Methods Retrospective cohort study. Early-stage NECC patients from 2006 to 2022 in our hospital were included and divided into Postoperative non-radiation group (Group A) and Postoperative radiation group (Group B). We use Kaplan-Meier method to analyze the progression-free survival (PFS), overall survival (OS), recurrence and OS rate.Results Sixty-six cases were included, 32 (48.5%) in Group A and 34 (51.5%) in Group B. After 35 (range 12–116) months follow-up, 26 (39.4%) had recurrence. Compared with Group A, Group B had lower pelvic recurrence rate (12.5% vs 2.9%, p = 0.142), higher distant recurrence rate (28.1% vs 44.1%, p = 0.177), and similar mortality rate (29.4% vs 31.3%, p = 0.871). Postoperative radiation in patients with cervical stromal invasion ≥1/2 showed an extended trend in PFS (33.9 months vs 47.9 months) and OS (40.7 months vs 70.0 months) but without statistical difference (p = 0.963, p = 0.636). Lymph-vascular space invasion (LVSI) is a high-risk factor for tumour recurrence (HR 9.13, p = 0.005), but radiation after surgery did not improve the PFS (51.5 months vs 48.8 months, p = 0.942) and OS (53.9 months vs 60.6 months, p = 0.715) in patients with LVSI.Limitations Retrospective study and relative small sample size.Conclusions Postoperative radiation seems to prolong PFS and OS in patients with cervical stromal invasion ≥1/2. LVSI was a high-risk factor for tumour recurrence, but radiation after surgery in patients with LVSI seems have no survival benefits. |
| format | Article |
| id | doaj-art-e0073aa6e50b406ea24deea91ecc1db9 |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-e0073aa6e50b406ea24deea91ecc1db92025-08-20T01:54:55ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2466667Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage diseaseXiaochen Song0Hui Zhang1Sen Zhong2Xianjie Tan3Shuiqing Ma4Ying Jin5Lingya Pan6Ming Wu7Dongyan Cao8Jiaxin Yang9Yang Xiang10Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaObjective The current treatment for early-stage neuroendocrine carcinoma of the cervix (NECC) mainly relies on operation and chemotherapy. We want to evaluate values of postoperative radiation in early-stage NECC.Methods Retrospective cohort study. Early-stage NECC patients from 2006 to 2022 in our hospital were included and divided into Postoperative non-radiation group (Group A) and Postoperative radiation group (Group B). We use Kaplan-Meier method to analyze the progression-free survival (PFS), overall survival (OS), recurrence and OS rate.Results Sixty-six cases were included, 32 (48.5%) in Group A and 34 (51.5%) in Group B. After 35 (range 12–116) months follow-up, 26 (39.4%) had recurrence. Compared with Group A, Group B had lower pelvic recurrence rate (12.5% vs 2.9%, p = 0.142), higher distant recurrence rate (28.1% vs 44.1%, p = 0.177), and similar mortality rate (29.4% vs 31.3%, p = 0.871). Postoperative radiation in patients with cervical stromal invasion ≥1/2 showed an extended trend in PFS (33.9 months vs 47.9 months) and OS (40.7 months vs 70.0 months) but without statistical difference (p = 0.963, p = 0.636). Lymph-vascular space invasion (LVSI) is a high-risk factor for tumour recurrence (HR 9.13, p = 0.005), but radiation after surgery did not improve the PFS (51.5 months vs 48.8 months, p = 0.942) and OS (53.9 months vs 60.6 months, p = 0.715) in patients with LVSI.Limitations Retrospective study and relative small sample size.Conclusions Postoperative radiation seems to prolong PFS and OS in patients with cervical stromal invasion ≥1/2. LVSI was a high-risk factor for tumour recurrence, but radiation after surgery in patients with LVSI seems have no survival benefits.https://www.tandfonline.com/doi/10.1080/07853890.2025.2466667Neuroendocrine carcinomacervical cancerradical hysterectomypostoperative radiation therapyoverall survival |
| spellingShingle | Xiaochen Song Hui Zhang Sen Zhong Xianjie Tan Shuiqing Ma Ying Jin Lingya Pan Ming Wu Dongyan Cao Jiaxin Yang Yang Xiang Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage disease Annals of Medicine Neuroendocrine carcinoma cervical cancer radical hysterectomy postoperative radiation therapy overall survival |
| title | Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage disease |
| title_full | Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage disease |
| title_fullStr | Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage disease |
| title_full_unstemmed | Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage disease |
| title_short | Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage disease |
| title_sort | neuroendocrine carcinoma of the cervix the value of postoperative radiation in early stage disease |
| topic | Neuroendocrine carcinoma cervical cancer radical hysterectomy postoperative radiation therapy overall survival |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2466667 |
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