Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation
Inflammation is a physiological response of the immune system to injury or infection but may become chronic. In general, inflammation is self-limiting and resolves by activating a termination program named resolution of inflammation. It has been argued that unresolved inflammation may be the basis o...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/829851 |
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| author | Denise Alves Perez Juliana Priscila Vago Rayssa Maciel Athayde Alesandra Corte Reis Mauro Martins Teixeira Lirlândia Pires Sousa Vanessa Pinho |
| author_facet | Denise Alves Perez Juliana Priscila Vago Rayssa Maciel Athayde Alesandra Corte Reis Mauro Martins Teixeira Lirlândia Pires Sousa Vanessa Pinho |
| author_sort | Denise Alves Perez |
| collection | DOAJ |
| description | Inflammation is a physiological response of the immune system to injury or infection but may become chronic. In general, inflammation is self-limiting and resolves by activating a termination program named resolution of inflammation. It has been argued that unresolved inflammation may be the basis of a variety of chronic inflammatory diseases. Resolution of inflammation is an active process that is fine-tuned by the production of proresolving mediators and the shutdown of intracellular signaling molecules associated with cytokine production and leukocyte survival. Apoptosis of leukocytes (especially granulocytes) is a key element in the resolution of inflammation and several signaling molecules are thought to be involved in this process. Here, we explore key signaling molecules and some mediators that are crucial regulators of leukocyte survival in vivo and that may be targeted for therapeutic purposes in the context of chronic inflammatory diseases. |
| format | Article |
| id | doaj-art-e0072861a20e4f229c8d413b0429d8ef |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e0072861a20e4f229c8d413b0429d8ef2025-08-20T02:21:07ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/829851829851Switching Off Key Signaling Survival Molecules to Switch On the Resolution of InflammationDenise Alves Perez0Juliana Priscila Vago1Rayssa Maciel Athayde2Alesandra Corte Reis3Mauro Martins Teixeira4Lirlândia Pires Sousa5Vanessa Pinho6Laboratório de Resolução da Resposta Inflamatória, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilLaboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilLaboratório de Resolução da Resposta Inflamatória, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilLaboratório de Resolução da Resposta Inflamatória, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilLaboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilLaboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilLaboratório de Resolução da Resposta Inflamatória, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilInflammation is a physiological response of the immune system to injury or infection but may become chronic. In general, inflammation is self-limiting and resolves by activating a termination program named resolution of inflammation. It has been argued that unresolved inflammation may be the basis of a variety of chronic inflammatory diseases. Resolution of inflammation is an active process that is fine-tuned by the production of proresolving mediators and the shutdown of intracellular signaling molecules associated with cytokine production and leukocyte survival. Apoptosis of leukocytes (especially granulocytes) is a key element in the resolution of inflammation and several signaling molecules are thought to be involved in this process. Here, we explore key signaling molecules and some mediators that are crucial regulators of leukocyte survival in vivo and that may be targeted for therapeutic purposes in the context of chronic inflammatory diseases.http://dx.doi.org/10.1155/2014/829851 |
| spellingShingle | Denise Alves Perez Juliana Priscila Vago Rayssa Maciel Athayde Alesandra Corte Reis Mauro Martins Teixeira Lirlândia Pires Sousa Vanessa Pinho Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation Mediators of Inflammation |
| title | Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation |
| title_full | Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation |
| title_fullStr | Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation |
| title_full_unstemmed | Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation |
| title_short | Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation |
| title_sort | switching off key signaling survival molecules to switch on the resolution of inflammation |
| url | http://dx.doi.org/10.1155/2014/829851 |
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