IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome
Background. Interleukin-37 (IL-37) acts as an inhibitor of innate and adaptive immunity. However, the exact role of IL-37 in the patients with acute coronary syndrome (ACS) remains to be elucidated. Methods. Patients were classified into 4 groups: normal coronary artery (NCA), stable angina (SA), un...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/9515346 |
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| author | Xiaobo Mao Ruirui Zhu Fangyuan Zhang Yucheng Zhong Kunwu Yu Yuzhen Wei Haitao Sun Wenbin Xu Quan Luo Yue Wang Yan Ding Qiutang Zeng |
| author_facet | Xiaobo Mao Ruirui Zhu Fangyuan Zhang Yucheng Zhong Kunwu Yu Yuzhen Wei Haitao Sun Wenbin Xu Quan Luo Yue Wang Yan Ding Qiutang Zeng |
| author_sort | Xiaobo Mao |
| collection | DOAJ |
| description | Background. Interleukin-37 (IL-37) acts as an inhibitor of innate and adaptive immunity. However, the exact role of IL-37 in the patients with acute coronary syndrome (ACS) remains to be elucidated. Methods. Patients were classified into 4 groups: normal coronary artery (NCA), stable angina (SA), unstable angina (UA), and acute myocardial infarction (AMI). The circulating Treg, Th1, and Th17 frequencies were measured. The effect of IL-37 on stimulated peripheral blood mononuclear cells (PBMCs) and the influence of IL-37 on DCs were explored. In addition, the role of IL-37-treated tDCs on Treg cell expansion and the stability of these tDCs were also tested. Results. Our results showed that the circulating Treg frequencies were decreased, while Th1 and Th17 frequencies were increased in ACS patients, and that IL-37 expanded Tregs but suppressed Th1 and Th17 cells in activated PBMCs derived from ACS patients. Of note, IL-37-treated human DCs obtained a tolerogenic phenotype, and such tDCs promoted expansion of Tregs and decreased the Th1 and Th17 populations when cocultured with CD4+ T cells. Interestingly, IL-37-treated DCs from patients with ACS are phenotypically and functionally comparable to IL-37-treated DCs from NCA patients, and tolerogenic properties of IL-37-treated DCs were highly stable. Conclusion. In conclusion, our results reveal a beneficial role of IL-37 in the patients with ACS and suggest that autologous IL-37-treated tDCs may be a novel therapeutic strategy for the patients with ACS. |
| format | Article |
| id | doaj-art-e006372af59f4caab41af5669bcf7efe |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e006372af59f4caab41af5669bcf7efe2025-08-20T03:26:05ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/95153469515346IL-37 Plays a Beneficial Role in Patients with Acute Coronary SyndromeXiaobo Mao0Ruirui Zhu1Fangyuan Zhang2Yucheng Zhong3Kunwu Yu4Yuzhen Wei5Haitao Sun6Wenbin Xu7Quan Luo8Yue Wang9Yan Ding10Qiutang Zeng11Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaBackground. Interleukin-37 (IL-37) acts as an inhibitor of innate and adaptive immunity. However, the exact role of IL-37 in the patients with acute coronary syndrome (ACS) remains to be elucidated. Methods. Patients were classified into 4 groups: normal coronary artery (NCA), stable angina (SA), unstable angina (UA), and acute myocardial infarction (AMI). The circulating Treg, Th1, and Th17 frequencies were measured. The effect of IL-37 on stimulated peripheral blood mononuclear cells (PBMCs) and the influence of IL-37 on DCs were explored. In addition, the role of IL-37-treated tDCs on Treg cell expansion and the stability of these tDCs were also tested. Results. Our results showed that the circulating Treg frequencies were decreased, while Th1 and Th17 frequencies were increased in ACS patients, and that IL-37 expanded Tregs but suppressed Th1 and Th17 cells in activated PBMCs derived from ACS patients. Of note, IL-37-treated human DCs obtained a tolerogenic phenotype, and such tDCs promoted expansion of Tregs and decreased the Th1 and Th17 populations when cocultured with CD4+ T cells. Interestingly, IL-37-treated DCs from patients with ACS are phenotypically and functionally comparable to IL-37-treated DCs from NCA patients, and tolerogenic properties of IL-37-treated DCs were highly stable. Conclusion. In conclusion, our results reveal a beneficial role of IL-37 in the patients with ACS and suggest that autologous IL-37-treated tDCs may be a novel therapeutic strategy for the patients with ACS.http://dx.doi.org/10.1155/2019/9515346 |
| spellingShingle | Xiaobo Mao Ruirui Zhu Fangyuan Zhang Yucheng Zhong Kunwu Yu Yuzhen Wei Haitao Sun Wenbin Xu Quan Luo Yue Wang Yan Ding Qiutang Zeng IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome Mediators of Inflammation |
| title | IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome |
| title_full | IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome |
| title_fullStr | IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome |
| title_full_unstemmed | IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome |
| title_short | IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome |
| title_sort | il 37 plays a beneficial role in patients with acute coronary syndrome |
| url | http://dx.doi.org/10.1155/2019/9515346 |
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