Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery
Background: Patients with pancreatic cancer are at increased risk of malnutrition and functional decline. This study aimed to identify preoperative nutritional and functional risk factors associated with postoperative complications. Methods: Adult patients with pancreatic cancer admitted to two univ...
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2025-05-01
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| author | Irene Lidoriki Maximos Frountzas Eva Karanikki Adam Mylonakis Alexandros Kozadinos Iliana Tsikrikou Maria Kyriakidou Lysandros Karydakis Dimitrios Stefanoudakis Maria Lampou Michail Vailas Evangelos Felekouras Konstantinos G. Toutouzas Dimitrios Schizas |
| author_facet | Irene Lidoriki Maximos Frountzas Eva Karanikki Adam Mylonakis Alexandros Kozadinos Iliana Tsikrikou Maria Kyriakidou Lysandros Karydakis Dimitrios Stefanoudakis Maria Lampou Michail Vailas Evangelos Felekouras Konstantinos G. Toutouzas Dimitrios Schizas |
| author_sort | Irene Lidoriki |
| collection | DOAJ |
| description | Background: Patients with pancreatic cancer are at increased risk of malnutrition and functional decline. This study aimed to identify preoperative nutritional and functional risk factors associated with postoperative complications. Methods: Adult patients with pancreatic cancer admitted to two university surgical departments in Athens, Greece, were included. Preoperative laboratory values, nutritional status, and functional status were assessed. Results: Among 96 patients included in this study, postoperative complications occurred in 69 (71.9%). Complication rates were significantly higher in patients with severe malnutrition (87.9% vs. 62.7%, <i>p</i> = 0.015), low Geriatric Nutritional Risk Index (GNRI) (90.5% vs. 66.2%, <i>p</i> = 0.023), low handgrip strength (91.7% vs. 61.5%, <i>p</i> = 0.037), and low gait speed (90.5% vs. 63.6%, <i>p</i> = 0.027). Major complications were linked to lower hemoglobin (Hb) (11.5 ± 1.9 vs. 12.8 ± 1.7 g/dL, <i>p</i> = 0.001), lower hematocrit (HCT) (34.7 ± 5.4% vs. 38.4 ± 4.7%, <i>p</i> = 0.001), and severe malnutrition (42.4% vs. 23.7%, <i>p</i> = 0.05). Lower Hb, lower HCT, malnutrition, and greater waist circumference were associated with postoperative mortality. Longer hospital stays were correlated with weaker handgrip strength and slower gait speed. Conclusion: Preoperative malnutrition and impaired functional status are significant predictors of adverse postoperative outcomes in pancreatic cancer surgery. |
| format | Article |
| id | doaj-art-dffff55d479646db95760c8ac29ec964 |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-dffff55d479646db95760c8ac29ec9642025-08-20T03:47:59ZengMDPI AGLife2075-17292025-05-0115580310.3390/life15050803Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer SurgeryIrene Lidoriki0Maximos Frountzas1Eva Karanikki2Adam Mylonakis3Alexandros Kozadinos4Iliana Tsikrikou5Maria Kyriakidou6Lysandros Karydakis7Dimitrios Stefanoudakis8Maria Lampou9Michail Vailas10Evangelos Felekouras11Konstantinos G. Toutouzas12Dimitrios Schizas13Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USAFirst Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration General Hospital, 11527 Athens, GreeceFirst Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration General Hospital, 11527 Athens, GreeceFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, GreeceFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, GreeceFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, GreeceFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, GreeceFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, GreeceFirst Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration General Hospital, 11527 Athens, GreeceDivision of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USAFirst Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration General Hospital, 11527 Athens, GreeceFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, GreeceFirst Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration General Hospital, 11527 Athens, GreeceFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 11527 Athens, GreeceBackground: Patients with pancreatic cancer are at increased risk of malnutrition and functional decline. This study aimed to identify preoperative nutritional and functional risk factors associated with postoperative complications. Methods: Adult patients with pancreatic cancer admitted to two university surgical departments in Athens, Greece, were included. Preoperative laboratory values, nutritional status, and functional status were assessed. Results: Among 96 patients included in this study, postoperative complications occurred in 69 (71.9%). Complication rates were significantly higher in patients with severe malnutrition (87.9% vs. 62.7%, <i>p</i> = 0.015), low Geriatric Nutritional Risk Index (GNRI) (90.5% vs. 66.2%, <i>p</i> = 0.023), low handgrip strength (91.7% vs. 61.5%, <i>p</i> = 0.037), and low gait speed (90.5% vs. 63.6%, <i>p</i> = 0.027). Major complications were linked to lower hemoglobin (Hb) (11.5 ± 1.9 vs. 12.8 ± 1.7 g/dL, <i>p</i> = 0.001), lower hematocrit (HCT) (34.7 ± 5.4% vs. 38.4 ± 4.7%, <i>p</i> = 0.001), and severe malnutrition (42.4% vs. 23.7%, <i>p</i> = 0.05). Lower Hb, lower HCT, malnutrition, and greater waist circumference were associated with postoperative mortality. Longer hospital stays were correlated with weaker handgrip strength and slower gait speed. Conclusion: Preoperative malnutrition and impaired functional status are significant predictors of adverse postoperative outcomes in pancreatic cancer surgery.https://www.mdpi.com/2075-1729/15/5/803nutritional statusfunctional statuspancreatic cancercomplicationsmorbiditymortality |
| spellingShingle | Irene Lidoriki Maximos Frountzas Eva Karanikki Adam Mylonakis Alexandros Kozadinos Iliana Tsikrikou Maria Kyriakidou Lysandros Karydakis Dimitrios Stefanoudakis Maria Lampou Michail Vailas Evangelos Felekouras Konstantinos G. Toutouzas Dimitrios Schizas Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery Life nutritional status functional status pancreatic cancer complications morbidity mortality |
| title | Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery |
| title_full | Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery |
| title_fullStr | Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery |
| title_full_unstemmed | Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery |
| title_short | Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery |
| title_sort | exploring the link between nutritional and functional status and short term postoperative outcomes in patients undergoing pancreatic cancer surgery |
| topic | nutritional status functional status pancreatic cancer complications morbidity mortality |
| url | https://www.mdpi.com/2075-1729/15/5/803 |
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