Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbits
Abstract Objective This study aimed to compare the regenerative effect of autogenous micro-dentin and nano-dentin particles on bone regeneration in rabbits’ mandibular defects. Sixty adult New Zealand rabbits were randomly divided into three groups: a control group, a micro-dentin group, and a nano-...
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| Language: | English |
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BMC
2025-03-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-025-07191-6 |
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| author | Sarah Yasser Altaib Abd al razik Mohammed Samy El-Safty Ahmed Shon Redhwan Saleh Al-Gabri Ahmed Yaseen Alqutaibi Hasnaa Fouad Reda G. Saleh |
| author_facet | Sarah Yasser Altaib Abd al razik Mohammed Samy El-Safty Ahmed Shon Redhwan Saleh Al-Gabri Ahmed Yaseen Alqutaibi Hasnaa Fouad Reda G. Saleh |
| author_sort | Sarah Yasser |
| collection | DOAJ |
| description | Abstract Objective This study aimed to compare the regenerative effect of autogenous micro-dentin and nano-dentin particles on bone regeneration in rabbits’ mandibular defects. Sixty adult New Zealand rabbits were randomly divided into three groups: a control group, a micro-dentin group, and a nano-dentin group. A critical-sized bony defect was created at the lower border of the mandible. Bone regeneration was evaluated at two, four, and eight weeks using light microscopy, cone beam computed tomography (CBCT) scans, and histomorphometric analysis. Results Nano-dentin significantly enhanced bone density and defect closure, as evidenced by CBCT and histological analyses. At eight weeks, it promoted extensive new bone formation, nearly bridging the defect, with minimal residual graft material compared to the micro-dentin group. Histomorphometric analysis confirmed its superior osteogenic potential, demonstrating enhanced bone regeneration and graft resorption. These findings highlight nano-dentin as a highly effective biomaterial for mandibular bone repair. |
| format | Article |
| id | doaj-art-dff5a0d518704b6fbb4d68f6a99c753b |
| institution | DOAJ |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-dff5a0d518704b6fbb4d68f6a99c753b2025-08-20T02:49:30ZengBMCBMC Research Notes1756-05002025-03-0118111110.1186/s13104-025-07191-6Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbitsSarah Yasser0Altaib Abd al razik Mohammed1Samy El-Safty2Ahmed Shon3Redhwan Saleh Al-Gabri4Ahmed Yaseen Alqutaibi5Hasnaa Fouad6Reda G. Saleh7Oral Biology Department, Faculty of Dentistry, Tanta UniversityOral and Maxillofacial Surgery Department, Faculty of Oral and Dental Medicine, Qena UniversityDental Biomaterials Department, Faculty of Dentistry, Tanta UniversityRemovable Prosthodontics Department, Faculty of Dental Medicine, AL-Azhar UniversityProsthodontic Department, Faculty of Dentistry, Ibb UniversityProsthodontic Department, Faculty of Dentistry, Ibb UniversityOral Biology Department, Faculty of Dentistry, Tanta UniversityOral Biology Department, Faculty of Dentistry, Tanta UniversityAbstract Objective This study aimed to compare the regenerative effect of autogenous micro-dentin and nano-dentin particles on bone regeneration in rabbits’ mandibular defects. Sixty adult New Zealand rabbits were randomly divided into three groups: a control group, a micro-dentin group, and a nano-dentin group. A critical-sized bony defect was created at the lower border of the mandible. Bone regeneration was evaluated at two, four, and eight weeks using light microscopy, cone beam computed tomography (CBCT) scans, and histomorphometric analysis. Results Nano-dentin significantly enhanced bone density and defect closure, as evidenced by CBCT and histological analyses. At eight weeks, it promoted extensive new bone formation, nearly bridging the defect, with minimal residual graft material compared to the micro-dentin group. Histomorphometric analysis confirmed its superior osteogenic potential, demonstrating enhanced bone regeneration and graft resorption. These findings highlight nano-dentin as a highly effective biomaterial for mandibular bone repair.https://doi.org/10.1186/s13104-025-07191-6Bone regenerationMicro-dentin particlesNano-dentin particlesCritical size bone defectNanotechnologyCBCT, EDX |
| spellingShingle | Sarah Yasser Altaib Abd al razik Mohammed Samy El-Safty Ahmed Shon Redhwan Saleh Al-Gabri Ahmed Yaseen Alqutaibi Hasnaa Fouad Reda G. Saleh Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbits BMC Research Notes Bone regeneration Micro-dentin particles Nano-dentin particles Critical size bone defect Nanotechnology CBCT, EDX |
| title | Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbits |
| title_full | Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbits |
| title_fullStr | Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbits |
| title_full_unstemmed | Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbits |
| title_short | Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbits |
| title_sort | comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in new zealand rabbits |
| topic | Bone regeneration Micro-dentin particles Nano-dentin particles Critical size bone defect Nanotechnology CBCT, EDX |
| url | https://doi.org/10.1186/s13104-025-07191-6 |
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